Normal and abnormal development of the male urogenital tract. Role of androgens, mesenchymal-epithelial interactions, and growth factors.
Normal and abnormal development of the male urogenital tract. Role of androgens, mesenchymal-epithelial interactions, and growth factors.
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DOI：
10.1002/j.1939-4640.1992.tb00338.x
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发表时间：
1992-11
影响因子：
--
通讯作者：
Gerald R. Cunha;Elaine T. Alarid;Timothy Turner;A. Donjacour;E. Boutin;B. A. Foster
中科院分区：
文献类型：
--
作者：
Gerald R. Cunha;Elaine T. Alarid;Timothy Turner;A. Donjacour;E. Boutin;B. A. Foster
雄激素依赖性男性泌尿生殖发育通过间充质-上皮相互作用发生，其中间充质诱导上皮形态发生，调节上皮增殖，并引起组织特异性分泌蛋白的表达。间充质-上皮相互作用在成年期仍然很重要。例如，泌尿生殖窦（UGM）和精囊（SVM）的间充质可诱导各种成体上皮细胞发生显着的形态和功能变化。由于成体上皮细胞无疑对间充质有反应，间充质可以引发替代形态和功能表型的表达，因此已形成的癌也可能受到其结缔组织环境的影响。对此，Dunning前列腺肿瘤已通过UGM或SVM诱导分化为高柱状分泌上皮细胞。细胞分化的这种变化与生长速率的降低和肿瘤发生的丧失相关。讨论了可溶性生长因子在间充质-上皮相互作用机制中的作用。
Androgen-dependent male urogenital development occurs via mesenchymal-epithelial interactions in which mesenchyme induces epithelial morphogenesis, regulates epithelial proliferation, and evokes expression of tissue-specific secretory proteins. Mesenchymal-epithelial interactions continue to be important into adulthood. For example, mesenchyme of the urogenital sinus (UGM) and seminal vesicle (SVM) induce dramatic morphologic and functional changes in various adult epithelia. Since adult epithelial cells are unquestionably responsive to mesenchymes that can elicit expression of alternative morphologic and functional phenotypes, established carcinomas might also be influenced by their connective tissue environment. In this regard, Dunning prostatic tumor has been induced by UGM or SVM to differentiate into tall columnar secretory epithelial cells. This change in cytodifferentiation is associated with a reduction in growth rate and loss of tumorigenesis. The role of soluble growth factors in the mechanism of mesenchymal-epithelial interactions is discussed.