Validation of Fully Automatic Quantitative Software for Finger Joint Space Narrowing Progression for Rheumatoid Arthritis Patients.
Validation of Fully Automatic Quantitative Software for Finger Joint Space Narrowing Progression for Rheumatoid Arthritis Patients.
复制标题
类风湿关节炎患者手指关节间隙狭窄进展的全自动定量软件的验证。
DOI：
10.1007/s10278-020-00390-6
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Kamishima T.
中科院分区：
文献类型：
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作者：
Narisawa C;Sutherland K;Lu Y;Furusaki A;Sagawa A;Kamishima T.
在类风湿性关节炎（RA）中，关节间隙狭窄（JSN）的放射学进展采用目视评估进行评价。然而，这些方法复杂且耗时。我们开发了一个自动系统，可以检测关节位置和计算关节空间差异指数（JSDI），这是定义为在两个X线片之间的JSN的时间变化。本研究的目的是建立一个软件，自动评估的JSN的时间变化的有效性。本研究包括39例RA患者。所有患者均接受托珠单抗治疗，并在0、6和12个月时接受手部X线摄影（分别为左手和右手）。由一名肌肉骨骼放射科医生和我们的自动系统使用mTSS（改良总夏普评分）对JSN进行评价。软件测量显示0 ~ 12个月JSDI显著高于0 ~ 6个月（p< 0.01）。mTSS在0、6、12个月间差异无统计学意义。在0个月时疾病活动度较高的组在0至6个月之间的JSDI显著高于疾病活动度较低的组（p= 0.02）。该软件可自动评估RA患者在X线片上手指关节的JSN进展。
In rheumatoid arthritis (RA), the radiographic progression of joint space narrowing (JSN) is evaluated using visual assessments. However, those methods are complicated and time-consuming. We developed an automatic system that can detect joint locations and compute the joint space difference index (JSDI), which was defined as the chronological change in JSN between two radiographs. The purpose of this study was to establish the validity of the software that automatically evaluates the temporal change of JSN. This study consisted of 39 patients with RA. All patients were treated with tocilizumab and underwent hand radiography (left and right hand separately) at 0, 6, and 12 months. The JSN was evaluated using mTSS (modified Total Sharp Score) by one musculoskeletal radiologist as well as our automatic system. Software measurement showed that JSDI between 0 and 12 months was significantly higher than that between 0 and 6 months (p< 0.01). While, there was no significant difference in mTSS between 0, 6, and 12 months. The group with higher disease activity at 0 months had significantly higher JSDI between 0 and 6 months than that with lower disease activity (p= 0.02). The automatic software can evaluate JSN progression of RA patients in the finger joint on X-ray.