TCF/LEF Transcription Factors: An Update from the Internet Resources.
TCF/LEF Transcription Factors: An Update from the Internet Resources.
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DOI：
10.3390/cancers8070070
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发表时间：
2016-07-20
期刊：
影响因子：
5.2
通讯作者：
Korinek V
中科院分区：
文献类型：
--
作者：
Hrckulak D;Kolar M;Strnad H;Korinek V
来自高迁移率族（HMG）盒家族的T细胞因子/淋巴增强子结合因子（TCF/LEF）蛋白（TCF）充当Wnt信号传导途径的主要下游效应物。哺乳动物TCF/LEF家族包括四种核因子，分别命名为TCF 7、LEF 1、TCF 7 L1和TCF 7 L2（也分别称为TCF 1、LEF 1、TCF 3和TCF 4）。这些蛋白质显示出共同的结构特征，并且通常以重叠模式表达，这意味着它们是冗余的。在基因靶向研究中确实观察到了这种冗余;然而，单个家族成员也表现出相关蛋白质无法重现的独特特征。在目前的观点，我们总结了我们目前的知识，个别TCF的具体功能，即结构功能研究，翻译后修饰，相互作用的合作伙伴，并在小鼠基因靶向后获得的表型。此外，我们采用了几个公开的数据库和网络工具，以评估在人类细胞和组织中的TCF/LEF家族成员的基因特异性亚型的表达模式和生产。
T-cell factor/lymphoid enhancer-binding factor (TCF/LEF) proteins (TCFs) from the High Mobility Group (HMG) box family act as the main downstream effectors of the Wnt signaling pathway. The mammalian TCF/LEF family comprises four nuclear factors designated TCF7, LEF1, TCF7L1, and TCF7L2 (also known as TCF1, LEF1, TCF3, and TCF4, respectively). The proteins display common structural features and are often expressed in overlapping patterns implying their redundancy. Such redundancy was indeed observed in gene targeting studies; however, individual family members also exhibit unique features that are not recapitulated by the related proteins. In the present viewpoint, we summarized our current knowledge about the specific features of individual TCFs, namely structural-functional studies, posttranslational modifications, interacting partners, and phenotypes obtained upon gene targeting in the mouse. In addition, we employed several publicly available databases and web tools to evaluate the expression patterns and production of gene-specific isoforms of the TCF/LEF family members in human cells and tissues.