Pretreatment levels of circulating Th1 and Th2 cytokines, and their ratios, are associated with ER-negative and triple negative breast cancers.
Pretreatment levels of circulating Th1 and Th2 cytokines, and their ratios, are associated with ER-negative and triple negative breast cancers.
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DOI：
10.1007/s10549-013-2549-3
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发表时间：
2013-06
影响因子：
3.8
通讯作者：
Ambrosone, Christine B.
中科院分区：
文献类型：
--
作者：
Hong, Chi-Chen;Yao, Song;McCann, Susan E.;Dolnick, Ree Y.;Wallace, Paul K.;Gong, Zhihong;Quan, Lei;Lee, Kelvin P.;Evans, Sharon S.;Repasky, Elizabeth A.;Edge, Stephen B.;Ambrosone, Christine B.
乳腺肿瘤的免疫特征因雌激素受体 (ER) 状态而异。本研究的目的是评估 ER 表型与协调细胞介导的 [T 辅助细胞 1 型 (Th1)] 和体液 [T 辅助细胞 2 型 (Th2)] 免疫的细胞因子循环水平之间的关联。我们对 523 名新诊断乳腺癌的女性进行了病例间比较，以评估使用 Luminex XMap 技术测量的 27 种循环细胞因子与乳腺癌表型之间的关联 [ER− 与 ER+；三阴性乳腺癌 (TNBC) 与 Luminal A (LumA)]。还评估了 Th1 与 Th2 细胞因子的比率。 ER− 肿瘤中的白细胞介素 (IL)-5（一种 Th-2 细胞因子）水平高于 ER+ 肿瘤。与 ER+ 和 LumA 癌症相比，IL-5 的最高三分位数分别与 ER−（OR = 2.33，95 % CI 1.40–3.90）和 TNBC（OR = 2.78，95 % CI 1.53–5.06）相关性更强，特别是在绝经前女性中（OR = 4.17，95 % CI） 1.86–9.34，ER− 与 ER+；OR = 5.60，95% CI 2.09–15.01，TNBC 与 LumA）。在患有 ER− 和 TNBC 的女性中也检测到了升高的 Th1 细胞因子，其中干扰素 α2（OR = 2.39，95% CI 1.31–4.35）或肿瘤坏死因子-α（OR = 2.27，95% CI 1.21–4.26）最高三分位的女性患 TNBC 的可能性是 LumA 癌症的两倍。当检查细胞因子比率时，与 ER+ 或 LumA 癌症相比，Th1 细胞因子与 IL-5 水平比率最高的女性分别患 ER− 或 TNBC 的可能性最低。关联性最强的是绝经前女性，她们患 TNBC 的可能性比 LumA 癌症低 80%（IL-12p40/IL-5，OR = 0.19，95% CI 0.07–0.56）。这些发现表明，免疫功能与 ER− 和 TNBC 相关，并且可能在年轻女性中最为相关，因为她们很可能被诊断出患有这些侵袭性表型。
Immune signatures in breast tumors differ by estrogen receptor (ER) status. The purpose of this study was to assess associations between ER phenotypes and circulating levels of cytokines that co-ordinate cell-mediated [T-helper type 1 (Th1)] and humoral [T-helper type 2 (Th2)] immunity. We conducted a case–case comparison of 523 women with newly diagnosed breast cancer to evaluate associations between 27 circulating cytokines, measured using Luminex XMap technology, and breast cancer phenotypes [ER− vs. ER+; triple negative breast cancer (TNBC) vs. luminal A (LumA)]. Ratios of Th1 to Th2 cytokines were also evaluated. Levels of interleukin (IL)-5, a Th-2 cytokine, were higher in ER− than in ER+ tumors. The highest tertile of IL-5 was more strongly associated with ER− (OR = 2.33, 95 % CI 1.40–3.90) and TNBCs (OR = 2.78, 95 % CI 1.53–5.06) compared to ER+ and LumA cancers, respectively, particularly among premenopausal women (OR = 4.17, 95 % CI 1.86–9.34, ER− vs. ER+; OR = 5.60, 95 % CI 2.09–15.01, TNBC vs. LumA). Elevated Th1 cytokines were also detected in women with ER− and TNBCs, with women in the highest tertile of interferon α2 (OR = 2.39, 95 % CI 1.31–4.35) or tumor necrosis factor-α (OR = 2.27, 95 % CI 1.21–4.26) being twice as likely to have TNBC versus LumA cancer. When cytokine ratios were examined, women with the highest ratios of Th1 cytokines to IL-5 levels were least likely to have ER− or TNBCs compared to ER+ or LumA cancers, respectively. The strongest associations were in premenopausal women, who were up to 80 % less likely to have TNBC than LumA cancers (IL-12p40/IL-5, OR = 0.19, 95 % CI 0.07–0.56). These findings indicate that immune function is associated with ER− and TNBC and may be most relevant among younger women, who are likely to be diagnosed with these aggressive phenotypes.
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影响因子：
2.8
作者：
Cai, Yeping;Zhou, Jiansheng;Webb, Dianne C.
通讯作者：
Webb, Dianne C.
影响因子：
45.3
作者：
Bianchini, Giampaolo;Qi, Yuan;Pusztai, Lajos
通讯作者：
Pusztai, Lajos
DOI：
10.1073/pnas.0901329106
发表时间：
2009-06-02
影响因子：
11.1
作者：
Critchley-Thorne, Rebecca J.;Simons, Diana L.;Lee, Peter P.
通讯作者：
Lee, Peter P.
影响因子：
2.6
作者：
Bleotu, Coralia;Chifiriuc, Mariana Carmen;Cernescu, Costin
通讯作者：
Cernescu, Costin
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y