Hematopoietic Radiation Syndrome in the Gottingen Minipig
Hematopoietic Radiation Syndrome in the Gottingen Minipig
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DOI：
10.1667/rr2481.1
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发表时间：
2011-07-01
影响因子：
3.4
通讯作者：
Whitnall, Mark H.
中科院分区：
文献类型：
--
作者：
Moroni, Maria;Coolbaugh, Thea V.;Whitnall, Mark H.
Additional large animal models for the acute radiation syndrome (ARS) would facilitate countermeasure development. We demonstrate here that Gottingen minipigs develop hematopoietic ARS symptoms similar to those observed in canines, non-human primates (NHPs) and humans. Dosimetry for whole-body gamma irradiation (0.6 Gy/min) was performed using electronic paramagnetic resonance (EPR) with alanine; National Institute of Standards and Technology (NIST)-calibrated alanine pellets and water-filled Plexiglas phantoms were used. After irradiations of 1.6-2.0 Gy, blood pancytopenia was observed for several weeks, accompanied by the characteristic ARS stages: prodromal symptoms, latent period, illness and recovery or morbidity. Morbidity occurred between days 14 and 27, with a preliminary LD50/30 estimate between 1.7 and 1.9 Gy. The criterion of whether platelet counts were
