Molecular MRI of Thrombosis.
Molecular MRI of Thrombosis.
复制标题
DOI：
10.1007/s12410-010-9061-5
复制
发表时间：
2010
影响因子：
0.9
通讯作者：
Caravan, Peter
中科院分区：
文献类型：
--
作者：
Ciesienski, Katie L;Caravan, Peter
本文综述了近年来使用靶向MRI探针进行血栓无创分子成像的方法。探针设计策略进行了讨论：选择分子靶;纳米粒子与小分子探针;和钆与氧化铁成像记者。这些不同的设计策略的例子是从最近的文献中选择的。已经描述了用于成像与纤维蛋白的直接和间接结合以及与活化血小板的直接结合的新型造影剂。重点放在已在动物模型或人体临床试验中证明实用性的探针上。
This review focuses on recent approaches in using targeted MRI probes for noninvasive molecular imaging of thrombosis. Probe design strategies are discussed: choice of molecular target; nanoparticle versus small-molecule probe; and gadolinium versus iron oxide imaging reporter. Examples of these different design strategies are chosen from the recent literature. Novel contrast agents used to image direct and indirect binding to fibrin have been described as well as direct binding to activated platelets. Emphasis is placed on probes where utility has been demonstrated in animal models or in human clinical trials.