Sex Hormones Are Associated with Right Ventricular Structure and Function The MESA-Right Ventricle Study
Sex Hormones Are Associated with Right Ventricular Structure and Function The MESA-Right Ventricle Study
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DOI：
10.1164/rccm.201007-1027oc
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发表时间：
2011-03-01
影响因子：
24.7
通讯作者：
Kawut, Steven M.
中科院分区：
文献类型：
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作者：
Ventetuolo, Corey E.;Ouyang, Pamela;Kawut, Steven M.
基本原理：性激素对左心室有影响，但对右心室（RV）的影响尚不清楚。目的：我们假设性激素与无心血管疾病的大型队列中的RV形态相关。方法：采用免疫分析法测定性激素水平，测定右室射血分数（RVEF）、每搏输出量（RVSV）、体质量、舒张末期容积，通过心脏磁共振成像测量了1,957名男性和1,738名绝经后女性的收缩末期容积（RVESV）。每种激素与RV参数之间的关系通过多元线性回归进行评估。测量和主要结果：较高的雌二醇水平与较高的RVEF相关（13/1 In[nmol/L]，0.88; 95%置信区间[CI]，0.32 - 1.43; P = 0.002）和较低RVESV（13/1 In[nmo 1/1]，-0.87; 95% CI，-1.67至-0.08; P = 0.03）。在男性中，较高的生物可利用睾酮水平与较高的RVSV（每1 In的β [nmol/L]，1.97; 95% CI，0.20至3.73; P = 0.03）和较大的RV质量和体积0.01）相关。较高的脱氢表雄酮水平与较高的RVSV（β/1 In[nmol/L]，1.37; 95%CI，0.15 - 2.59; P = 0.03）和较大的RV质量（0/1 In[nmol/L]，0.25; 95%CI，0.00 - 0.49; P = 0.05）和体积（P
Rationale: Sex hormones have effects on the left ventricle, but hormonal influences on the right ventricle (RV) are unknown.Objectives: We hypothesized that sex hormones would be associated with RV morphology in a large cohort free of cardiovascular disease.Methods: Sex hormones were measured by immunoassay and RV ejection fraction (RVEF), stroke volume (RVSV), mass, end-diastolic volume, and end-systolic volume (RVESV) were measured by cardiac magnetic resonance imaging in 1,957 men and 1,738 postmenopausal women. The relationship between each hormone and RV parameter was assessed by multivariate linear regression.Measurements and Main Results: Higher estradiol levels were associated with higher RVEF (13 per 1 In[nmol/L], 0.88; 95% confidence interval [CI], 0.32 to 1.43; P = 0.002) and lower RVESV (13 per 1 In[nmo1/1], -0.87; 95% CI, -1.67 to -0.08; P = 0.03) in women using hormone therapy. In men, higher bioavailable testosterone levels were associated with higher RVSV (beta per 1 In[nmol/L], 1.97; 95% CI, 0.20 to 3.73; P = 0.03) and greater RV mass and volumes 0.01). Higher dehydroepiandrosterone levels were associated with higher RVSV (beta per 1 In[nmol/L], 1.37; 95% CI, 0.15 to 2.59; P = 0.03) and greater RV mass (0 per 1 In[nmol/L], 0.25; 95% CI, 0.00 to 0.49; P = 0.05) and volumes (P