Mechanism of skull suture maintenance and interdigitation
Mechanism of skull suture maintenance and interdigitation
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DOI：
10.1111/j.1469-7580.2009.01148.x
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发表时间：
2009-12-01
影响因子：
2.4
通讯作者：
Shiota, Kohei
中科院分区：
文献类型：
--
作者：
Miura, Takashi;Perlyn, Chad A.;Shiota, Kohei
颅骨缝作为生长中心，其功能涉及多个分子途径。在大脑生长期间，这些缝合线保持薄而直，后来发展出复杂的分形交错，提供了互锁的力量。分子间相互作用和缝合线图案形成之间的关系的本质尚不清楚。在这里，我们表明，通过将所涉及的分子分为两组，稳定因子和底物分子，复杂的分子网络可以模拟一个简单的两种反应扩散模型，概括了所有已知的缝合模式形成的行为。该模型再现了早期阶段薄缝合组织的维持，随后修改直缝合以形成骨性交错，以及分形结构的形成。从该模型的预测是在良好的协议与实验观察，表明该模型捕捉的交错过程的本质。
Skull sutures serve as growth centers whose function involves multiple molecular pathways. During periods of brain growth the sutures remain thin and straight, later developing complex fractal interdigitations that provide interlocking strength. The nature of the relationship between the molecular interactions and suture pattern formation is not understood. Here we show that by classifying the molecules involved into two groups, stabilizing factors and substrate molecules, complex molecular networks can be modeled by a simple two-species reaction-diffusion model that recapitulates all the known behavior of suture pattern formation. This model reproduces the maintenance of thin sutural tissue at early stages, the later modification of the straight suture to form osseous interdigitations, and the formation of fractal structures. Predictions from the model are in good agreement with experimental observations, indicating that the model captures the essential nature of the interdigitation process.