Aldosterone: good guy or bad guy in cerebrovascular disease?
Aldosterone: good guy or bad guy in cerebrovascular disease?
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醛固酮：脑血管疾病的好人还是坏人？
DOI：
10.1016/j.tem.2005.09.002
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Dorrance,AnneM
中科院分区：
文献类型：
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作者：
Rigsby,ChristinéS;Cannady,WilliamE;Dorrance,AnneM
中风是西方世界残疾的主要原因，但治疗干预的选择很少。醛固酮在中风发病机制中所起的复杂作用开始显现。慢性盐皮质激素受体（MR）阻滞剂可降低出血性卒中的发生率和缺血性卒中引起的损伤的严重程度。这似乎是一种血管现象，因为MR阻断增加了血管腔直径，这可能会增加组织的血流和灌注，以减少缺血性损伤。然而，MR拮抗作用提供的血管保护与脑内观察到的结果不一致，脑内需要MR激活才能使神经元存活。这两种不同的效应都可能对中风有治疗意义。
Stroke is a leading cause of disability in the Western world, yet the choices for therapeutic intervention are few. The complex role played by aldosterone in the pathogenesis of stroke is beginning to emerge. Chronic mineralocorticoid receptor (MR) blockade reduces the incidence of hemorrhagic strokes and the severity of damage caused by ischemic strokes. This appears to be a vascular phenomenon because MR blockade increases vessel lumen diameter, which presumably increases blood flow and perfusion of the tissue to reduce ischemic damage. However, the vascular protection afforded by MR antagonism is at odds with the results seen within the brain, where MR activation is required for neuronal survival. Both of these divergent effects have possible therapeutic implications for stroke.