Development and function of cortical thymic epithelial cells.
Development and function of cortical thymic epithelial cells.
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DOI：
10.1007/82_2013_322
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发表时间：
2014
影响因子：
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通讯作者：
K. Takada;I. Ohigashi;M. Kasai;H. Nakase;Y. Takahama
中科院分区：
文献类型：
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作者：
K. Takada;I. Ohigashi;M. Kasai;H. Nakase;Y. Takahama
The thymic cortex provides a microenvironment that supports the generation and T cell antigen receptor (TCR)-mediated selection of CD4+CD8+TCRαβ+thymocytes. Cortical thymic epithelial cells (cTECs) are the essential component that forms the architecture of the thymic cortex and induces the generation as well as the selection of newly generated T cells. Here we summarize current knowledge on the development, function, and heterogeneity of cTECs, focusing on the expression and function of β5t, a cTEC-specific subunit of the thymoproteasome.
