Modulating Aβ33-42 Peptide Assembly by Graphene Oxide
Modulating Aβ33-42 Peptide Assembly by Graphene Oxide
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DOI：
10.1002/chem.201402022
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发表时间：
2014-06-10
影响因子：
4.3
通讯作者：
Dong, Mingdong
中科院分区：
文献类型：
--
作者：
Li, Qiang;Liu, Lei;Dong, Mingdong
氧化石墨烯（GO）用作调节剂以调节淀粉样蛋白原纤维（A β（33-42））的形成和发展。原子力显微镜时间演化测量揭示，肽单体和GO片的大的可用表面之间的初始结合可以重定向淀粉样蛋白β的组装途径。该结果支持开发石墨烯基材料以抑制淀粉样变性的可能性。
Graphene oxide (GO) is utilized as the modulator to tune the formation and development of amyloid fibrils (A beta(33-42)). Atomic force microscopy temporal evolution measurements reveal that the initial binding between the peptide monomer and the large available surface of the GO sheets can redirect the assembly pathway of amyloid beta. The results support the possibility to develop graphene-based materials to inhibit amyloidosis.