Asymmetric Patterns of Visual Field Defect in Primary Open-Angle and Primary Angle-Closure Glaucoma
Asymmetric Patterns of Visual Field Defect in Primary Open-Angle and Primary Angle-Closure Glaucoma
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DOI：
10.1167/iovs.17-22980
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发表时间：
2018-03-01
影响因子：
4.4
通讯作者：
Asaoka, Ryo
中科院分区：
文献类型：
--
作者：
Yousefi, Siamak;Sakai, Hiroshi;Asaoka, Ryo
目的。比较所有严重程度的原发性开角型青光眼 (POAG) 和原发性闭角型青光眼 (PACG) 的视野 (VF) 丧失的半视野不对称性。方法。共纳入 327 名 POAG 患者的 522 只眼（平均年龄 +/- SD，54.1 +/- 12.4 岁）和 204 名 PACG 患者的 375 只眼（平均年龄 +/- SD，54.1 +/- 12.4 岁）（67.3 +/- 8.9 岁）。符合 POAG 或 PACG 定义的受试者被纳入。计算 POAG 和 PACG 眼的早期 (>= -6 dB)、中度 (< -6 dB 和 >= -12 dB) 和晚期 (< -12 dB) 阶段青光眼 Hemifield 测试 (GHT) 区域的总偏差 (TD) 值 (Humphrey 24-2 VF) 的平均值。然后计算POAG和PACG眼的上半视野GHT区域和下半视野GHT区域之间的TD值的差异。此外，还比较了 POAG 和 PACG 之间的模式 SD (PSD) 和平均 TD (mTD) 值之间的关系。结果。早期POAG眼中，上半视野的三个区域（中央、旁中央和周围）比下半视野损失更大；在中度和晚期阶段，上半场的所有 GHT 区域都比下半场的损失更大。在PACG眼中，与POAG相比，上半视野明显较差的区域明显少于下半视野：早期有1个区域（中央），中期有2个区域（中央和周边），晚期有1个区域（中央）。对于给定的 TD 值平均值，POAG 眼的 PSD 值高于 PACG 眼。结论。在 POAG 和 PACG 眼中，上半视野的 VF 损伤比下半视野更明显；然而，这种趋势在 POAG 眼中比在 PACG 眼中更为明显。
PURPOSE. To compare the hemifield asymmetry of visual field (VF) loss in primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) across all severity levels.METHODS. A total of 522 eyes of 327 patients with POAG (mean age +/- SD, 54.1 +/- 12.4 years) and 375 eyes of 204 patients with PACG (67.3 +/- 8.9 years) were included. Subjects meeting the definitions of POAG or PACG were included. Means of the total deviation (TD) values (Humphrey 24-2 VF) in the Glaucoma Hemifield Test (GHT) regions were calculated in early (>= -6 dB), moderate (< -6 dB and >= -12 dB), and advanced (< -12 dB) stages of POAG and PACG eyes. Then the differences of the TD values between superior and inferior hemifield GHT regions of POAG and PACG eyes were calculated. Also, the relationship between the values of pattern SD (PSD) and mean TD (mTD) was compared between POAG and PACG.RESULTS. In POAG eyes in the early stage, three regions (central, paracentral, and peripheral) in the superior hemifield had greater loss than their inferior counterparts; in moderate and advanced stages, all GHT regions in the superior hemifield had greater loss than their inferior counterparts. In PACG eyes, siginificantly fewer regions in the superior hemifield were significantly worse than their inferior counterpart, compared with POAG: one region (central) in early stage, two regions (central and peripheral) in moderate stage, and one region (central) in advanced stage. POAG eyes had greater PSD values than PACG eyes for given mean of TD values.CONCLUSIONS. In both POAG and PACG eyes, VF damage was more pronounced in superior hemifield than inferior hemifield; however, this tendency was more obvious in POAG eyes than in PACG eyes.