Potential targeting of B7-H4 for the treatment of cancer.
Potential targeting of B7-H4 for the treatment of cancer.
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DOI：
10.1111/imr.12530
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发表时间：
2017-03
影响因子：
8.7
通讯作者：
Miller SD
中科院分区：
文献类型：
--
作者：
Podojil JR;Miller SD
注意到肿瘤内存在白色血细胞浸润的观察可追溯到世纪以上，然而调节肿瘤免疫的细胞和分子机制仍在继续阐明。最近成功使用单克隆抗体阻断免疫调节途径以增强肿瘤特异性免疫应答用于治疗癌症，这鼓励了对另外的免疫调节受体/配体途径的鉴定。在过去的几年中，越来越多的数据已经确定B7-H4（VTCN 1/B7 x/B7 S1）作为治疗癌症的潜在治疗靶点。B7-H4的潜在临床意义得到了在许多肿瘤组织中发现的高水平B7-H4表达以及肿瘤细胞上的表达水平与不良临床和病理特征（包括肿瘤侵袭性）的相关性的支持。B7-H4的生物学活性与炎性CD 4 + T细胞应答降低以及肿瘤微环境中表达B7-H4的肿瘤相关巨噬细胞和FoxP 3+调节性T细胞（T细胞）之间的相关性相关。由于B7-H4在各种癌症类型的肿瘤细胞和肿瘤相关巨噬细胞上表达，因此B7-H4的治疗性阻断可以有利地改变肿瘤微环境，从而允许抗原特异性清除肿瘤细胞。本综述强调了靶向B7-H4的治疗潜力。
Observations noting the presence of white blood cell infiltrates within tumors date back more than a century, however the cellular and molecular mechanisms regulating tumor immunity continue to be elucidated. The recent successful use of monoclonal antibodies to block immune regulatory pathways to enhance tumor-specific immune responses for the treatment of cancer has encouraged the identification of additional immune regulatory receptor/ligand pathways. Over the past several years, a growing body of data has identified B7-H4 (VTCN1/B7x/B7S1) as a potential therapeutic target for the treatment of cancer. The potential clinical significance of B7-H4 is supported by the high levels of B7-H4 expression found in numerous tumor tissues and correlation of the level of expression on tumor cells with adverse clinical and pathologic features, including tumor aggressiveness. The biological activity of B7-H4 has been associated with decreased inflammatory CD4+ T-cell responses and a correlation between B7-H4-expressing tumor-associated macrophages and FoxP3+ regulatory T cells (Tregs) within the tumor microenvironment. Since B7-H4 is expressed on tumor cells and tumor-associated macrophages in various cancer types, therapeutic blockade of B7-H4 could favorably alter the tumor microenvironment allowing for antigen-specific clearance tumor cells. The present review highlights the therapeutic potential of targeting B7-H4.
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影响因子：
4.3
作者：
ElShamy WM;Sinha A;Said N
通讯作者：
Said N
共刺激分子B7-H1、B7-H3、B7-H4在人胰腺癌中的共表达及其临床意义
影响因子：
4
作者：
Chen Y;Sun J;Zhao H;Zhu D;Zhi Q;Song S;Zhang L;He S;Kuang Y;Zhang Z;Li D
通讯作者：
Li D
DOI：
10.1084/jem.20090847
发表时间：
2009-12-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Francisco LM;Salinas VH;Brown KE;Vanguri VK;Freeman GJ;Kuchroo VK;Sharpe AH
通讯作者：
Sharpe AH
影响因子：
--
作者：
Cheng, Chen;Qu, Qiu-Xia;Huang, Jian-An
通讯作者：
Huang, Jian-An
DOI：
10.1056/nejmoa1200694
发表时间：
2012-06-28
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brahmer JR;Tykodi SS;Chow LQ;Hwu WJ;Topalian SL;Hwu P;Drake CG;Camacho LH;Kauh J;Odunsi K;Pitot HC;Hamid O;Bhatia S;Martins R;Eaton K;Chen S;Salay TM;Alaparthy S;Grosso JF;Korman AJ;Parker SM;Agrawal S;Goldberg SM;Pardoll DM;Gupta A;Wigginton JM
通讯作者：
Wigginton JM