Functional connectivity of the frontoparietal network predicts cognitive modulation of pain.
Functional connectivity of the frontoparietal network predicts cognitive modulation of pain.
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DOI：
10.1016/j.pain.2012.12.004
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发表时间：
2013-03
期刊：
影响因子：
7.4
通讯作者：
Gollub RL
中科院分区：
文献类型：
--
作者：
Kong J;Jensen K;Loiotile R;Cheetham A;Wey HY;Tan Y;Rosen B;Smoller JW;Kaptchuk TJ;Gollub RL
疼痛的体验可能会受到预期（预测线索）的显著影响。这种调节疼痛的能力有可能对治疗性镇痛产生实质性影响，并构成非药物性疼痛缓解的基础。在这项研究中，我们调查1）在疼痛的预期，疼痛管理和疼痛评级过程中参与疼痛视觉线索调制的脑区;和2）测试前静息状态功能连接和疼痛评级的线索效应的大小之间的关联。我们发现，线索条件化后，视觉线索可以显着调节主观疼痛评级。fMRI结果表明，与额顶叶网络相关的脑区（前额叶和顶叶皮层）和疼痛/情绪调节区（头端前扣带皮层，rACC）参与了疼痛预期和给药阶段的线索调制。最有趣的是，我们发现，测试前静息状态功能之间的连接额顶叶网络（如独立成分分析所确定的）和rACC/MPFC与疼痛评级变化的线索效应呈正相关。我们相信，这些发现将为我们理解个体之间的可变线索/预期效应以及大脑的内在连接如何影响预期诱导的疼痛调制提供新的思路。
The experience of pain can be significantly influenced by expectancy (predictive cues). This ability to modulate pain has the potential to affect therapeutic analgesia substantially and constitutes a foundation for non-pharmacological pain relief. In this study, we investigated 1) brain regions involved in visual cue modulation of pain during anticipation of pain, pain administration, and pain rating; and 2) the association between pre-test resting-state functional connectivity and the magnitude of cue effects on pain ratings. We found that after cue conditioning, visual cues can significantly modulate subjective pain ratings. fMRI results suggested that brain regions pertaining to the frontoparietal network (prefrontal and parietal cortex) and a pain/emotion modulatory region (rostral anterior cingulate cortex, rACC) are involved in cue modulation during both pain anticipation and administration stage. Most interestingly, we found that pre-test resting state functional connectivity between the frontoparietal network (as identified by independent component analysis) and the rACC/MPFC was positively associated with cue effects on pain rating changes. We believe that these finding will shed new light on our understanding of variable cue/expectancy effects across individuals and how the intrinsic connectivity of the brain may influence expectancy induced modulation of pain.
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影响因子：
3.2
作者：
Kalisch, R;Wiech, K;Dolan, RJ
通讯作者：
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影响因子：
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