The elusive concept of brain connectivity
The elusive concept of brain connectivity
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DOI：
10.1016/s1053-8119(03)00112-5
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发表时间：
2003-06-01
期刊：
影响因子：
5.7
通讯作者：
Horwitz, B
中科院分区：
文献类型：
--
作者：
Horwitz, B
神经元和神经群不会像孤岛一样独立运作。相反，它们通过传入和传出连接以一种协调的方式与其他这样的元素相互作用，从而使不同的感觉运动和认知任务得以执行。引入了功能连通性的概念和有效连通性的相关概念来指定这种相互作用的功能优势。功能神经成像方法，特别是PET和fMRI，已被广泛用于评估大脑不同区域之间的功能连通性。在简要回顾了这些大脑连接概念的历史之后，我认为功能性和有效连接的概念性表述还远远不够清晰。具体来说，术语功能性和有效连通性适用于在空间、时间和其他特征上变化的功能成像数据类型（例如PET、fMRI、EEG）上计算的数量，使用不同的定义（即使是相同模态的数据）并采用不同的计算算法。在了解每个定义在潜在的神经基质方面的含义之前，跨研究的功能和/或有效连接的比较可能会出现不一致，应该非常谨慎地进行。(C) 2003 Elsevier Science（美国）版权所有。
Neurons and neural populations do not function as islands onto themselves. Rather, they interact with other such elements through their afferent and efferent connections in an orchestrated manner so as to enable different sensorimotor and cognitive tasks to be performed. The concept of functional connectivity and the allied notion of effective connectivity were introduced to designate the functional strengths of such interactions. Functional neuroimaging methods, especially PET and fMRI, have been used extensively to evaluate the functional connectivity between different brain regions. After providing a brief historical review of these notions of brain connectivity, I argue that the conceptual formulations of functional and effective connectivity are far from clear. Specifically, the terms functional and effective connectivity are applied to quantities computed on types of functional imaging data (e.g., PET, fMRI, EEG) that vary in spatial, temporal, and other features, using different definitions (even for data of the same modality) and employing different computational algorithms. Until it is understood what each definition means in terms of an underlying neural substrate, comparisons of functional and/or effective connectivity across studies may appear inconsistent and should be performed with great caution. (C) 2003 Elsevier Science (USA). All rights reserved.