Markers of Novelty Processing in Older Adults Are Stable and Reliable
Markers of Novelty Processing in Older Adults Are Stable and Reliable
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DOI：
10.3389/fnagi.2019.00165
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发表时间：
2019-06-28
影响因子：
4.8
通讯作者：
Daffner, Kirk R.
中科院分区：
文献类型：
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作者：
Behforuzi, Hura;Feng, Nicole C.;Daffner, Kirk R.
探索行为和对新奇事物的反应在维持老年人的认知功能方面发挥着重要作用。对新奇事物的神经和行为反应中与年龄或疾病相关的差异的推断通常基于单次实验测试的结果。关于这些发现是否代表所研究人群的稳定特征的研究非常有限，如果研究人员要确定旨在促进探索行为的干预措施的结果或就不同临床群体之间的新颖性处理差异得出适当的结论，这一点至关重要。本研究的目的是调查认知正常老年人事件相关电位（ERP）和对新刺激的行为反应的短期重测可靠性。记录了 70 名健康老年人在相隔 7 周进行的两次会议期间参与受试者控制的视觉新奇奇怪任务的 ERP 和观看持续时间。在每次治疗期间测量平均中线 P3 振幅和潜伏期、连续 50 ms 间隔期间的平均中线振幅、从主成分分析 (PCA) 得出的时空因素以及对新刺激的反应的观看持续时间。方差分析 (ANOVA) 显示时间 1 和时间 2 之间的任何测量值均无可靠差异。时间 1 和时间 2 之间的组内相关系数 (ICC) 在平均 P3 振幅 (ICC = 0.86)、与 P3 分量一致的两个时空因素 (ICC 为 0.88 和 0.76) 以及新刺激的观看持续时间 (ICC = 0.81) 方面表现出色。仅 P3 峰值延迟 (ICC = 0.56) 的可靠性是公平的。从 100 到 1,000 毫秒的连续 50 毫秒平均幅度测量产生了相当到优异的可靠性，并且除了确定的 12 个时空因素之一之外，所有其他因素都表明 ICC 处于良好到优异的范围内。我们得出的结论是，老年人在 7 周内表现出 ERP 和对新视觉刺激的行为反应的稳定性。这些结果表明，老年人可能有一种处理新奇事物的特有方式，这种方式似乎能够抵抗环境或内部状态的短暂变化，而这些变化可以在单次测试期间被索引。建立可靠的新颖性处理措施将使研究人员能够确定拟议的干预措施是否对行为的这一重要方面产生影响。
Exploratory behavior and responsiveness to novelty play an important role in maintaining cognitive function in older adults. Inferences about age- or disease-related differences in neural and behavioral responses to novelty are most often based on results from single experimental testing sessions. There has been very limited research on whether such findings represent stable characteristics of populations studied, which is essential if investigators are to determine the result of interventions aimed at promoting exploratory behaviors or draw appropriate conclusions about differences in the processing of novelty across diverse clinical groups. The goal of the current study was to investigate the short-term test-retest reliability of event-related potential (ERP) and behavioral responses to novel stimuli in cognitively normal older adults. ERPs and viewing durations were recorded in 70 healthy older adults participating in a subject-controlled visual novelty oddball task during two sessions occurring 7 weeks apart. Mean midline P3 amplitude and latency, mean midline amplitude during successive 50 ms intervals, temporospatial factors derived from principal component analysis (PCA), and viewing duration in response to novel stimuli were measured during each session. Analysis of variance (ANOVA) revealed no reliable differences in the value of any measurements between Time 1 and 2. Intraclass correlation coefficients (ICCs) between Time 1 and 2 were excellent for mean P3 amplitude (ICC = 0.86), the two temporospatial factors consistent with the P3 components (ICC of 0.88 and 0.76) and viewing duration of novel stimuli (ICC = 0.81). Reliability was only fair for P3 peak latency (ICC = 0.56). Successive 50 ms mean amplitude measures from 100 to 1,000 ms yielded fair to excellent reliabilities, and all but one of the 12 temporospatial factors identified demonstrated ICCs in the good to excellent range. We conclude that older adults demonstrate substantial stability in ERP and behavioral responses to novel visual stimuli over a 7-week period. These results suggest that older adults may have a characteristic way of processing novelty that appears resistant to transient changes in their environment or internal states, which can be indexed during a single testing session. The establishment of reliable measures of novelty processing will allow investigators to determine whether proposed interventions have an impact on this important aspect of behavior.