Mevinolin: A Highly Specific Inhibitor of Microsomal 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase of Radish Plants
Mevinolin: A Highly Specific Inhibitor of Microsomal 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase of Radish Plants
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DOI：
10.1515/znc-1982-1-209
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发表时间：
1982-02
期刊：
影响因子：
--
通讯作者：
T. Bach;H. Lichtenthaler
中科院分区：
文献类型：
--
作者：
T. Bach;H. Lichtenthaler
The fungal metabolite mevinolin, known to be a potent hypocholesterolemic agent, excerts in vitro a strong inhibitory effect on microsomal HMG-CoA reductase from etiolated radish seedlings at a concentration of about three magnitudes lower than the Km towards the natural substrate (S)-HMG-CoA (I50 = 2.5 × 10-9 ᴍ). Beside this, mevinolin significantly inhibits the root elongation of radish as well as of wheat seedlings already at low concentrations of 10 to 100 ppb (= 2.5 × 10-8 to 2.5 × 10-7 ᴍ).
