Regulation of the acute production of steroids in steroidogenic cells.
Regulation of the acute production of steroids in steroidogenic cells.
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DOI：
10.1210/edrv-17-3-221
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发表时间：
1996-06
影响因子：
20.3
通讯作者：
D. Stocco;B. Clark
中科院分区：
文献类型：
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作者：
D. Stocco;B. Clark
调节响应于营养激素刺激的类固醇产生的机制已经是三十多年来的研究主题。在考虑营养激素对类固醇生成过程的影响时，有必要首先区分急性影响和慢性影响。急性效应是指在激素刺激下导致非常快速（在几分钟内）合成和分泌类固醇的效应，并涉及细胞内胆固醇快速转运至其裂解位点，如下文所述。慢性效应是指发生时间为数小时至数十小时的效应，涉及参与类固醇生物合成的蛋白质的基因转录和翻译增加。这一章将集中在研究旨在阐明的机制参与的急性调节类固醇生产响应激素刺激。几篇优秀的综述文章概述了慢性刺激对类固醇生成酶的影响（Simpson和Waterman 1983;米勒1988; Hanukoglu 1992）。
The mechanism regulating the production of steroids in response to trophic hormone stimulation has been the subject of investigation for over three decades. When considering the effects of trophic hormones on the steroidogenic process it is necessary to first distinguish between acute effects and chronic effects. Acute effects are those which result in the very rapid (within minutes) synthesis and secretion of steroids in response to hormone stimulation and involve the rapid translocation of intracellular cholesterol to the site of its cleavage, as will be discussed later. Chronic effects are those which occur on the order of hours to tens of hours and involve increased gene transcription and translation of the proteins involved in the biosynthesis of steroids. This chapter will focus on studies designed to elucidate the mechanisms involved in the acute regulation of steroid production in response to hormone stimulation. Overviews of the effects of chronic stimulation on steroidogenic enzymes have appeared in several excellent review articles (Simpson and Waterman 1983; Miller 1988; Hanukoglu 1992).