Mild-to-moderate hypertriglyceridemia in young men is associated with endothelial dysfunction and increased plasma concentrations of asymmetric dimethylarginine
Mild-to-moderate hypertriglyceridemia in young men is associated with endothelial dysfunction and increased plasma concentrations of asymmetric dimethylarginine
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DOI：
10.1016/s0735-1097(01)01318-3
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发表时间：
2001-07-01
影响因子：
24
通讯作者：
Tornvall, P
中科院分区：
文献类型：
--
作者：
Lundman, P;Eriksson, MJ;Tornvall, P
本研究的目的是研究轻中度高脂血症健康年轻男性的内皮功能和颈总动脉内膜中层厚度（IMT）。血浆不对称二甲基精氨酸（ADMA），内源性一氧化氮合酶抑制剂，测量，以进一步阐明所涉及的mechanisms involved.Background高胆固醇血症是冠心病的危险因素，虽然背后的机制增加的风险仍有待确定。静脉脂肪负荷引起的血浆甘油三酯急性升高与内皮功能受损相关。研究结果检查急性高脂饮食或慢性hyperglyceridemia对内皮function.Methods的影响引起的急性影响是不一致的流量介导的血管舒张和硝酸甘油诱导的血管舒张的肱动脉和颈总动脉IMT的测量非侵入性超声技术在15 hyperglyceridemic（HTC）的主题和15个匹配的对照组，平均年龄34岁。结果HTG组血流介导的血管舒张功能降低（p < 0.0001），而硝酸甘油诱导的血管舒张功能和颈动脉IMT无显著差异。HTG组的不对称二甲基精氨酸浓度较高（p < 0.05）。结论青年男性高甘油三酯血症与内皮功能障碍和血浆ADMA浓度升高有关，但与颈总动脉IMT增加无关。推论是慢性高脂血症导致内皮功能障碍，可能是由于ADR IA浓度增加，并且在动脉粥样硬化的早期表现中，内皮功能障碍可能先于IMT增加。（J Am Coil Cardiol 2001; 38：111-6）（C）美国心脏病学会2001年。
OBJECTIVES The aim of this study was to investigate endothelial function and common carotid intima-media thickness (IMT) in healthy young men with mild-to-moderate hypertriglyceridemia. Plasma asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, was measured to further elucidate the mechanisms involved.BACKGROUND Hypertriglyceridemia is a risk factor for coronary heart disease although the mechanisms behind the increased risk remain to be defined. Acute elevation of plasma triglycerides induced by an intravenous fat load is associated with impaired endothelial function. The results of studies examining acute effects induced by a high-fat meal or effects of chronic hypertriglyceridemia on endothelial function are more inconsistent.METHODS Flow-mediated vasodilation and nitroglycerin-induced vasodilation of the brachial artery and common carotid IMT were measured noninvasively by ultrasound technique in 15 hypertriglyceridemic (HTC) subjects and 15 matched controls, mean age 34 years. Plasma concentrations of ADMA were measured by high-performance liquid chromatography.RESULTS Flow-mediated vasodilation was decreased in the HTG group (p < 0.0001), whereas nitroglycerin-induced vasodilation and carotid IMT did not differ significantly. Asymmetric dimethylarginine concentrations were higher in the HTG group (p < 0.05).CONCLUSIONS Hypertriglyceridemia in young men is associated with endothelial dysfunction and increased plasma concentration of ADMA but not with increased IMT of the common carotid artery. The corollary is that chronic hypertriglyceridemia results in endothelial dysfunction, possibly due to increased ADR IA concentration, and that endothelial dysfunction might precede increased IMT among the early manifestations of atherosclerosis. (J Am Coil Cardiol 2001; 38:111-6) (C) 2001 by the American College of Cardiology.