Cutting Edge: IL-1 Receptor Signaling is Critical for the Development of Autoimmune Uveitis.
Cutting Edge: IL-1 Receptor Signaling is Critical for the Development of Autoimmune Uveitis.
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DOI：
10.4049/jimmunol.1502080
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发表时间：
2016-01-15
期刊：
影响因子：
--
通讯作者：
Leonard WJ
中科院分区：
文献类型：
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作者：
Wan CK;He C;Sun L;Egwuagu CE;Leonard WJ
白细胞介素-1β (IL-1β)是一种促炎细胞因子，对局部和全身免疫都很重要。然而，这种细胞因子的异常产生与许多炎症性疾病的致病机制有关，包括behet病和年龄相关性黄斑变性。我们在此报告了在眼部炎症期间，中性粒细胞、巨噬细胞和树突状细胞在视网膜中分泌IL-1β的增加，并表明IL-1R信号的丧失可以保护实验性自身免疫性葡萄膜炎（EAU）。此外，在il1r缺陷小鼠中，EAU的改善与炎症细胞向视网膜的浸润减少和介导葡萄膜炎的致葡萄膜性Th17细胞数量减少有关。这些发现表明IL-1R阻滞剂可能用于眼部炎症性疾病的治疗。
Interleukin-1 beta (IL-1β) is a pro-inflammatory cytokine important for local and systemic immunity. However, aberrant production of this cytokine is implicated in pathogenic mechanisms of a number of inflammatory diseases including Behçet’s disease and age-related macular degeneration. We report here the increased secretion of IL-1β in the retina by neutrophils, macrophages, and dendritic cells during ocular inflammation and show that loss of IL-1R signaling confers protection from experimental autoimmune uveitis (EAU). Moreover, the amelioration of EAU in Il1r-deficient mice was associated with reduced infiltration of inflammatory cells into the retina and decreased numbers of uveitogenic Th17 cells that mediate uveitis. These findings indicate the possible utility of IL-1R blocking agents for the treatment of ocular inflammatory diseases.