Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62
Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62
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DOI：
10.1016/s0304-3940(03)00216-7
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发表时间：
2003-05-15
影响因子：
2.5
通讯作者：
Ikeda, K
中科院分区：
文献类型：
--
作者：
Arai, T;Nonaka, T;Ikeda, K
我们检测了5例泛素阳性、tau阴性包涵体的额颞叶痴呆（FTD）患者p62的免疫反应性。仅有1例有运动神经元病（MND）的临床表现。在所有病例中，海马区和大脑新皮层的泛素阳性神经元包涵体和神经突的p62免疫组织化学阳性。此外，在一例FTD合并MND的颞区，许多少突胶质细胞和一些星形胶质细胞p62阳性。这些结果表明，FTD的退行性过程涉及p62，并且该过程不仅发生在神经元中，也发生在胶质细胞中。(C) 2003爱思唯尔科学爱尔兰有限公司版权所有。
We examined the immunoreactivity of p62 in five cases of frontotemporal dementia (FTD) with ubiquitin-positive, tau-negative inclusions. Only one case had clinical features suggestive of motor neuron disease (MND). In all cases, ubiquitin-positive neuronal inclusions and neurites in the hippocampal region and cerebral neocortex were immunohistochemically positive for p62. Moreover, in the temporal region of a case of FTD with MND, many oligodendrocytes and some astrocytes were positive for p62. These results suggest that the degenerative process involves p62 in FTD and that the process takes place not only in neurons but also in glial cells. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.