A MODEL OF THE MECHANICS OF THE LEFT-VENTRICLE
A MODEL OF THE MECHANICS OF THE LEFT-VENTRICLE
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DOI：
10.1007/bf02364118
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发表时间：
1979-01-01
影响因子：
3.8
通讯作者：
VEENSTRA, PC
中科院分区：
文献类型：
--
作者：
ARTS, T;RENEMAN, RS;VEENSTRA, PC
建立了心肌力学与左心室泵功能关系的数学模型。特别注意左室压力和左室容积之间的关系以及肌节长度和纤维应力的跨壁分布。LV由8个同心壳体组成的厚壁圆柱体模拟。假设心肌材料是各向异性的。每一个壳体都考虑了LV壁上肌纤维的方向和顺序激活。通过圆柱体的上横截面表面相对于圆柱体的下横截面表面围绕圆柱体的轴线旋转来模拟基部相对于顶点围绕LV的轴线的扭转。扭转左心室是平衡肌节缩短和收缩末期纤维应力的跨壁差异的重要手段。当允许扭转时，肌节缩短和收缩末期纤维应力的跨壁差异分别<18%和16%。当扭转被阻止时，在大多数LV力学模型中，这些透壁差异分别增加到32%和42%。
The relation between cardiac muscle mechanics and left ventricular (LV) pump function is simulated by a mathematical model. Special attention is paid to the relation between LV pressure and LV volume and the transmural distribution of sarcomere length and fiber stress on the other. The LV is simulated by a thick-walled cylinder composed of 8 concentric shells. The myocardial material is assumed to be anisotropic. The orientation and sequential activation of the muscle fibers across the LV wall are considered per shell. Twisting of the base with respect to the apex around the axis of the LV is simulated by rotation of the upper cross-sectional surface of the cylinder with respect to the lower one around the axis of the cylinder. Twisting of the LV is an important means to equalize transmural differences in sarcomere shortening and end-systolic fiber stress. When torsion is allowed transmural differences in sarcomere shortening and end-systolic fiber stress are < 18 and 16%, respectively. When torsion is prevented, as in most of the models of LV-mechanics, these transmural differences increase up to 32 and 42%, respectively.