Benzothiazoles from Condensation of o-Aminothiophenoles with Carboxylic Acids and Their Derivatives: A Review.
Benzothiazoles from Condensation of o-Aminothiophenoles with Carboxylic Acids and Their Derivatives: A Review.
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O-氨基噻吩与羧酸及其衍生物的二苯甲酸唑磺酸盐的苯噻唑唑：综述。
DOI：
10.3390/molecules26216518
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发表时间：
2021-10-28
期刊：
影响因子：
--
通讯作者：
Cruz A
中科院分区：
文献类型：
--
作者：
García-Báez EV;Padilla-Martínez II;Tamay-Cach F;Cruz A
近年来，杂环化合物在合成多种具有生物活性的化合物中的应用引起了有机化学家的极大兴趣。杂环化合物广泛存在于自然界中，是生命所必需的。其中，一些天然含氮杂环化合物已被用作化疗剂。它们作为硫代糖苷或核苷类似物与糖分子的连接在重要的生物过程以及合成有机化学中起着重要作用。含有苯并噻唑（BT）核的分子是这类有趣的化合物，因为它们中的一些已被发现具有各种各样的生物活性。在这个意义上，我们选择了这个主题，然后回顾和总结的程序相关的邻氨基噻吩（ATP），以及它们的二硫化物与羧酸，酯，原酸酯，酰氯，酰胺，腈的缩合反应。包括与二氧化碳（CO2）的缩合反应。传统的方法与使用的酸和金属催化剂，以及最近的绿色技术，如微波辐射，使用离子液体，和超声（US）化学，已被证明有许多优点，在审查中发现。
Nowadays, organic chemists are interested in the field of heterocyclic chemistry due to its use in the synthesis of a great variety of biologically active compounds. Heterocyclic compounds are widely found in nature and are essential for life. Among these, some natural nitrogen containing heterocyclic compounds have been used as chemotherapeutic agents. Their attachment to sugar molecules either as thioglycosides or as nucleosides analogues plays an important role in vital biological processes as well as in synthetic organic chemistry. Molecules containing benzothiazole (BT) nuclei are of this interesting class of compounds because some of them have been found to have a wide variety of biological activities. In this sense, we selected this topic to review and to then summarize the procedures related to the condensation reactions of o-aminothiophenoles (ATPs) as well as their disulfides with carboxylic acids, esters, orthoesters, acyl chlorides, amides, and nitriles. The condensation reactions with carbon dioxide (CO2) are included. Conventional methods with the use of acid and metal catalysts as well as recent green techniques, such as microwave irradiation, the use of ionic liquids, and ultrasound (US) chemistry, which have proven to have many advantages, were found in the review.
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影响因子：
2
作者：
Billeau, S;Chatel, F;Galy, JP
通讯作者：
Galy, JP
影响因子：
2.1
作者：
BREMBILLA, A;ROIZARD, D;LOCHON, P
通讯作者：
LOCHON, P
影响因子：
1.8
作者：
Coelho, Felipe L.;Campo, Leandra F.
通讯作者：
Campo, Leandra F.
影响因子：
3.3
作者：
Bhat, Mahesh;Belagali, S. L.;Kumar, S. Mahadeva
通讯作者：
Kumar, S. Mahadeva
影响因子：
2
作者：
Chakraborti, AK;Selvam, C;Bhagat, S
通讯作者：
Bhagat, S