Pediatric high-grade gliomas
Pediatric high-grade gliomas
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DOI：
10.1007/s00112-008-1799-3
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发表时间：
2008-12-01
影响因子：
0.4
通讯作者：
van Gool, S.
中科院分区：
文献类型：
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作者：
Kramm, C.;Rausche, U.;van Gool, S.
儿童高级别神经胶质瘤由神经胶质来源的不同肿瘤实体组成，其特征在于恶性组织病理学表型或较差的临床过程。多形性胶质母细胞瘤、间变性星形细胞瘤和脑桥神经胶质瘤是最常见的儿童高级别神经胶质瘤。目前的治疗建议包括手术、放疗和化疗，但脑桥胶质瘤除外，仅通过放疗和化疗治疗。完整的肿瘤切除仍然具有最高的预后影响。尽管大多数患者的总体生存率仍然很差，但患有高级别神经胶质瘤的婴儿和幼儿通过常规化疗和手术表现出良好的总体生存率。对于这些患者，目前几个欧洲国家正在制定单独的化疗方案。对于老年患者，必须制定新的多模式治疗方案，其中包含创新的肿瘤特异性治疗策略以及常规治疗策略。
Pediatric high-grade gliomas comprise different tumor entities of glial origin that are characterized by their malignant histopathologic phenotype or poor clinical course. Glioblastoma multiforme, anaplastic astrocytoma, and pontine glioma represent the most frequent pediatric high-grade gliomas. Current treatment recommendations include surgery, radiotherapy, and chemotherapy, with the exception of pontine gliomas, which are treated solely by radiotherapy and chemotherapy. Complete tumor resection still has the highest prognostic impact. Although overall survival is still poor for most patients, infants and very young children with high-grade gliomas show good overall survival with conventional chemotherapy and surgery. For these patients, a separate chemotherapy protocol is currently being developed in several European countries. For older patients, new multimodal treatment protocols containing innovative tumor-specific as well as conventional treatment strategies must be established.