Emerging resistance to newer antimicrobial agents among Shigella isolated from Finnish foreign travellers
Emerging resistance to newer antimicrobial agents among Shigella isolated from Finnish foreign travellers
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DOI：
10.1017/s0950268807008862
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发表时间：
2008-04-01
影响因子：
4.2
通讯作者：
Siitonen, A.
中科院分区：
文献类型：
--
作者：
Haukka, K.;Siitonen, A.
在芬兰，大多数志贺氏菌病病例与出国旅行有关。对1990-2005年芬兰患者分离的1814株志贺氏菌进行了12种抗微生物药物的耐药性研究。自2000年以来，采用e -试验测定耐钠地酸菌株的环丙沙星最低抑菌浓度。多重耐药菌株（对>= 4种抗菌素耐药）的比例在中国和印度的分离株中最高，但在亚洲其他地区正在显著增加。对萘啶酸的耐药性在来自远东的菌株中已变得普遍，2004-2005年期间发现了第一批对环丙沙星耐药的分离株。所有耐环丙沙星菌株均为弗氏沙门氏菌2a血清型。所有耐钠地酸的弗氏沙门氏菌对环丙沙星的敏感性均降低，而23%耐钠地酸的索内沙门氏菌对环丙沙星仍完全敏感。
In Finland, most cases of shigellosis are related to travel abroad. Antimicrobial drug resistance of 1814 Shigella strains isolated from Finnish patients during 1990-2005 was studied using discs of 12 antimicrobial agents. Since 2000, the E-test has been performed to determine ciprofloxacin minimum inhibitory concentrations of nalidixic acid-resistant isolates. The proportion of multi-resistant strains (resistant to >= 4 antimicrobials) was highest among isolates from China and India, but is increasing significantly in other parts of Asia. Resistance to nalidixic acid has become common among the strains from the Far East, and the first isolates also resistant to ciprofloxacin were detected during 2004-2005. All the ciprofloxacin-resistant isolates belonged to the S.flexneri 2a serotype. All the nalidixic acid-resistant S.flexneri strains had reduced Susceptibility to ciprofloxacin, whereas 23% of the nalidixic acid-resistant S. sonnei strains were still completely susceptible to ciprofloxacin.