Preclinical Studies with 15‐Deoxyspergualin in Various Animal Models for Autoimmune Diseases
Preclinical Studies with 15‐Deoxyspergualin in Various Animal Models for Autoimmune Diseases
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15-脱氧精胍菌素在多种自身免疫性疾病动物模型中的临床前研究
DOI：
10.1111/j.1749-6632.1993.tb35862.x
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发表时间：
1993
影响因子：
5.2
通讯作者：
G. Dickneite
中科院分区：
文献类型：
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作者：
H. Schorlemmer;G. Dickneite
这种多胺化合物，(2)-L-氨基-19-胍-L，L-羟基-4，9，12-三氮杂-正十二烷-10，lt-二酮三盐酸盐，带有末端的鸟嘌呤基团，由Iaswatal首次描述。自从第一次观察到15-DSG的免疫抑制活性以来，根据其免疫药理学特性，15-DSG主要在不同动物物种的各种实验性器官移植模型中进行了测试。用这种免疫抑制药物治疗后，移植的异体和异种移植物的存活时间可以延长。短期1IDSG可诱导移植物持久的接受性和耐受性。免疫活性的脾或骨髓细胞移植通常由于自身免疫反应而导致移植物抗宿主(GVH)疾病的临床征象，但1dDSG在预防GVH疾病方面非常有效，甚至被证明对各种GVH疾病具有很强的治疗活性。下面，我们将对到目前为止所取得的有希望的成果进行概述。
This polyamine compound,(2)-l-amino-19-guanidino-l l-hydroxy-4, 9, 12-triazano-nadecane-l0, lt-dione trihydrochloride, carries a terminal guanidic group and was first described by Iwasawaetal. in 1982.'Since the first observation on its immunosuppressive activity, 2 and in view of its immunopharmacologic profile, 15-DSG was tested predominantly in various models of experimental organ transplantation in different animal species. Prolongation of transplanted allo-and xenograft survival after treatment with this immunosuppressive drug could be shown. Even long-lasting graft acceptance and tolerance could be induced after a short course of 1IDSG. Transplantation of immunocompetent spleen or bone marrow cells ordinarily leads to clinical signs of graft-versus-host (GvH) disease due to an autoimmune reaction, but, 1dDSG was very effective in the prevention of GvH diseases and even proved to have a strong therapeutic activity in various kinds of GvH di~ ease.~*'*~*~ In fact, 15-DSG was tested in most of the models of autoimmune disease that are available for study at present. In the following, we shall give an overview to the promising results obtained up to now.
使用 L3T4 单克隆抗体的 F(ab)2 片段治疗小鼠狼疮。
DOI：
--
发表时间：
1989
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Carteron,NL;Schimenti,CL;Wofsy,D
通讯作者：
Wofsy,D