A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo
A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo
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DOI：
10.1038/79738
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发表时间：
2000-10-01
影响因子：
30.5
通讯作者：
Cyster, JG
中科院分区：
文献类型：
--
作者：
Matloubian, M;David, A;Cyster, JG
我们描述了一种具有趋化因子特征的蛋白质，称为 CXCL16，它是由淋巴器官 T 细胞区的树突状细胞 (DC) 和脾红髓中的细胞产生的。 CXCL16 含有跨膜结构域，可产生膜结合型和可溶型两种形式。初始 CD8 T 细胞、自然杀伤 T 细胞和记忆 CD4 T 细胞的子集结合 CXCL16，活化的 T 细胞趋化性迁移至可溶性趋化因子。通过表达克隆，Bonzo（也称为 STRL33 和 TYMSTR）被鉴定为 CXCL16 受体。 CXCL16 可能具有促进 DC 和 CD8T 细胞之间的相互作用以及引导 T 细胞在脾红髓中运动的作用。 CXCL16 也在胸腺髓质和一些非淋巴组织中发现，表明其在胸腺细胞发育和效应 T 细胞运输中的作用。
We describe a protein with the hallmarks of a chemokine, designated CXCL16, that is made by dendritic cells (DCs) in lymphoid organ T cell zones and by cells in the splenic red pulp. CXCL16 contains a transmembrane domain and both membrane-bound and soluble forms are produced. Naive CD8 T cells, natural killer T cells and a subset of memory CD4 T cells bind CXCL16, and activated T cells migrated chemotactically to the soluble chemokine. By expression cloning, Bonzo (also known as STRL33 and TYMSTR) was identified as a CXCL16 receptor. CXCL16 may function in promoting interactions between DCs and CD8T cells and in guiding T cell movements in the splenic red pulp. CXCL16 was also found in the thymic medulla and in some nonlymphoid tissues, indicating roles in thymocyte development and effector T cell trafficking.