KLF6, a candidate tumor suppressor gene mutated in prostate cancer
KLF6, a candidate tumor suppressor gene mutated in prostate cancer
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DOI：
10.1126/science.1066326
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发表时间：
2001-12-21
期刊：
影响因子：
56.9
通讯作者：
Friedman, SL
中科院分区：
文献类型：
--
作者：
Narla, G;Heath, KE;Friedman, SL
Kruppel样因子6（KLF 6）是一种功能未知的锌指转录因子。在这里，我们表明，KLF 6基因突变的一个子集的人前列腺癌。杂合性丢失分析显示，一个KLF 6等位基因在77%（17/22）的原发性前列腺肿瘤中缺失。保留的KLF 6等位基因的序列分析显示，这些肿瘤中有71%发生突变。功能研究证实，野生型KLF 6以不依赖于p53的方式上调p21（WAF 1/CIP 1）并显著降低细胞增殖，而肿瘤衍生的KLF 6突变体则不然。我们的数据表明，KLF 6是一个肿瘤抑制基因参与人类前列腺癌。
Kruppel-like factor 6 (KLF6) is a zinc finger transcription factor of unknown function. Here, we show that the KLF6 gene is mutated in a subset of human prostate cancer. Loss-of-heterozygosity analysis revealed that one KLF6 allele is deleted in 77% (17 of 22) of primary prostate tumors. Sequence analysis of the retained KLF6 allele revealed mutations in 71% of these tumors. Functional studies confirm that whereas wild-type KLF6 up-regulates p21 (WAF1/CIP1) in a p53-independent manner and significantly reduces cell proliferation, tumor-derived KLF6 mutants do not. Our data suggest that KLF6 is a tumor suppressor gene involved in human prostate cancer.