Infiltrating CD4+T cells attenuate chemotherapy sensitivity in prostate cancer via CCL5 signaling
Infiltrating CD4+T cells attenuate chemotherapy sensitivity in prostate cancer via CCL5 signaling
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浸润性 CD4 T 细胞通过 CCL5 信号减弱前列腺癌的化疗敏感性
DOI：
10.1002/pros.23810
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发表时间：
2019-06-15
期刊：
影响因子：
2.8
通讯作者：
Jin, Jie
中科院分区：
文献类型：
--
作者：
Xiang, Peng;Jin, Song;Jin, Jie
多西他赛（Doc）化疗在前列腺癌（PCa）病例的一个子集中是有效的;然而，大多数患者最终对多西他赛产生耐药性。肿瘤免疫微环境和分泌的细胞因子在化疗耐药性的形成中发挥着重要作用。我们之前的研究表明，前列腺肿瘤微环境中的CD 4 + T细胞有助于PCa进展;同时，我们发现Doc治疗后肿瘤区域的CD 4 + T细胞浸润增加;然而，它们对PCa化疗敏感性的影响尚不清楚。本研究旨在探讨CD 4 + T细胞在前列腺癌化疗敏感性中的作用及其机制。
Chemotherapy with Docetaxel (Doc) is efficient in a subset of prostate cancer (PCa) cases; however, most patients ultimately develop resistance to Docetaxel. The tumor immune microenvironment and secreted cytokines play a substantial role in development of resistance to chemotherapy. Our previous study has demonstrated that CD4+ T cells in prostate tumor microenvironment contribute to PCa progression; meanwhile, we found increased CD4+ T‐cell infiltration in tumor area after Doc treatment; however, their effects on PCa chemosensitivity remain unclear. Here, we aim to explore the role and mechanisms of CD4+ T cells in PCa chemotherapy sensitivity.