Melatonin Treatment at Dry-off Improves Reproductive Performance Postpartum in High-producing Dairy Cows under Heat Stress Conditions
Melatonin Treatment at Dry-off Improves Reproductive Performance Postpartum in High-producing Dairy Cows under Heat Stress Conditions
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DOI：
10.1111/rda.12128
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发表时间：
2013-08-01
影响因子：
1.7
通讯作者：
Lopez-Gatius, F.
中科院分区：
文献类型：
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作者：
Garcia-Ispierto, I.;Abdelfatah, A.;Lopez-Gatius, F.
本研究旨在确定热应激条件下高产奶牛早期干脱期褪黑素处理对后续繁殖性能和产奶量的影响。在实验一中，为了研究褪黑素在泌乳奶牛体内的药代动力学，在妊娠第120-20天（4头/剂量组），将未处理、3剂、6剂、9剂和12剂（每剂18 mg褪黑素）皮下植入。试验二在暖季对25头小母牛和114头高产荷斯坦-弗里西亚奶牛进行试验。动物被随机分配到对照组(C)或褪黑素组(M)。M组动物在妊娠第220天接受9次（小母牛）或12次（奶牛）褪黑素植入。试验1中，12颗植入物组奶牛在处理第0 ~ 49天的最大褪黑激素浓度（C-max）和浓度曲线下面积（AUC(0 ~ 49d)）均高于其他各组，但各组间无显著差异。在实验二中，重复繁殖综合征的可能性(
The aim of this study was to determine the effect of melatonin treatment during the early dry-off period on subsequent reproductive performance and milk production in high-producing dairy cows under heat stress conditions. In experiment I, addressing the pharmacokinetics of melatonin treatment in lactating dairy cows, doses of untreated, 3, 6, 9 or 12 implants/animal (18-mg melatonin each implant) were given as subcutaneous implants on gestation day 120-20 multiparous lactating dairy cows (four cows/dose group). Experiment II was performed during the warm season on 25 heifers and 114 high milk-producing Holstein-Friesian cows. Animals were randomly assigned to a control (C) or melatonin group (M). Animals in the M group received nine implants (heifers) or 12 (cows) of melatonin on day 220 of gestation. In experiment I, cows in the 12 implants group showed a higher maximum melatonin concentration (C-max) and area under the concentration curve from treatment day 0 to day 49 (AUC(0-49d)) than those in the remaining groups, among which there were no significant differences in this variable. In experiment II, the likelihood of repeat breeding syndrome (