In Vitro and In Vivo Recording of Local Field Potential Oscillations in Mouse Hippocampus.
In Vitro and In Vivo Recording of Local Field Potential Oscillations in Mouse Hippocampus.
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DOI：
10.1002/9780470942390.mo120089
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发表时间：
2012-09-01
影响因子：
--
通讯作者：
Jones, M W
中科院分区：
文献类型：
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作者：
Forsyth, L H;Witton, J;Jones, M W
海马局部场电位（LFP）的振荡反映了组成神经元间和主细胞群的协调、有节奏的活动。因此，量化振荡模式和功率的变化提供了一个强大的度量，通过它来推断海马网络活动的机制和功能，在介观水平，桥接单神经元的研究，海马功能的行为测定。在这里，补充协议，使振荡产生在体外（切片和整个海马制备）和功能分析的海马电路在行为小鼠的机械分析。一起使用，这些协议提供了一个全面的视图海马表型在小鼠模型中，突出海马功能和功能障碍的振荡生物标志物。Curr.协议Mouse Biol.2：273-294 © 2012由John Wiley & Sons，Inc.
Oscillations in hippocampal local field potentials (LFP) reflect the coordinated, rhythmic activity of constituent interneuronal and principal cell populations. Quantifying changes in oscillatory patterns and power therefore provides a powerful metric through which to infer mechanisms and functions of hippocampal network activity at the mesoscopic level, bridging single-neuron studies to behavioral assays of hippocampal function. Here, complementary protocols that enable mechanistic analyses of oscillation generation in vitro (in slices and a whole hippocampal preparation) and functional analyses of hippocampal circuits in behaving mice are described. Used together, these protocols provide a comprehensive view of hippocampal phenotypes in mouse models, highlighting oscillatory biomarkers of hippocampal function and dysfunction. Curr. Protoc. Mouse Biol. 2:273-294 © 2012 by John Wiley & Sons, Inc.