Longitudinal clinical decline and baseline predictors in progressive supranuclear palsy.
Longitudinal clinical decline and baseline predictors in progressive supranuclear palsy.
复制标题
进行性核上性麻痹的纵向临床衰退和基线预测因素。
DOI：
10.1016/j.parkreldis.2023.105290
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发表时间：
2023
影响因子：
4.1
通讯作者：
中科院分区：
文献类型：
--
作者：
Pavone,Costanza;Weigand,StephenW;Ali,Farwa;Clark,HeatherM;Botha,Hugo;Machulda,MaryM;Savica,Rodolfo;Pham,NhaTrangThu;Grijalva,RosalieM;Schwarz,ChristopherG;Senjem,MatthewL;Agosta,Federica;Filippi,Massimo;Jack,CliffordR;
前言进行性核上性麻痹（PSP）与几种临床变异相关，这些临床变异是基于眼运动功能障碍、姿势不稳定、运动不能和认知功能障碍定义的，尽管对这些特征如何随时间进展知之甚少。我们的目的是评估这些核心的临床特征的演变跨变量和评估基线的临床和神经影像学预测progression. MethodsNine 3 PSP患者招募的神经退行性疾病研究组，马约诊所，并进行了两次访问1年，基线MRI和[18 F]flortaucipir PET。我们比较了PSP评定量表的基线和年临床变化率（总的，眼运动，步态/中线评分）和蒙特利尔认知评估，在PSP-理查森，PSP-皮质和PSP-皮质下变体之间，并评估变化率和基线区域成像之间的关系。但各组之间的变化率没有观察到差异。PSP评定量表总分和步态/中线评分在随访时和变化率方面存在组间差异，PSP-皮质下显示出最小的损伤和最慢的进展。在PSP-皮质中观察到最大的认知障碍。治疗试验的样本量估计值在PSP变体之间存在差异。更大的基线flortaucipir摄取，但不是体积，中脑和运动皮质相关的临床decline.ConclusionThe PSP Rating Scale和它的子分数可能是有用的标志物PSP变体的预后分层的速度更快。基线时的Flortaucipir成像可能有助于预测下降率。
IntroductionProgressive supranuclear palsy (PSP) is associated with several clinical variants defined based on ocular motor dysfunction, postural instability, akinesia, and cognitive dysfunction, although little is known about how these features progress over time. We aimed to assess the evolution of these core clinical features across variants and assess baseline clinical and neuroimaging predictors of progression.MethodsNinety-three PSP patients were recruited by the Neurodegenerative Research Group, Mayo Clinic, and underwent two visits 1-year apart, with baseline MRI and [18F]flortaucipir PET. We compared baseline and annualized rates of clinical change on the PSP Rating Scale (total, ocular motor, gait/midline scores) and Montreal Cognitive Assessment, across PSP-Richardson's, PSP-Cortical and PSP-Subcortical variants and assessed relationships between rates of change and baseline regional imaging.ResultsOcular motor scores differed across groups at baseline and follow-up, with lowest scores observed in PSP-subcortical, but no differences were observed in rate of change across groups. PSP Rating Scale total and gait/midline scores differed across groups at follow-up and in rates of change, with PSP-subcortical showing the least impairment and slowest progression. Greatest cognitive impairment was observed in PSP-Cortical. Sample size estimates for treatment trials differed across PSP variants. Greater baseline flortaucipir uptake, but not volume, of midbrain and motor cortex correlated with faster rates of clinical decline.ConclusionThe PSP Rating Scale and its subscores might be useful markers for the prognostic stratification of PSP variants. Flortaucipir imaging at baseline may help predict rate of decline.
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影响因子：
4
作者：
Whitwell,JenniferL
通讯作者：
Whitwell,JenniferL
影像学检查可预测进行性核上性麻痹的进展
影响因子：
8.6
作者：
J. Whitwell;Jia Xu;J. Mandrekar;J. Gunter;C. Jack;K. Josephs
通讯作者：
K. Josephs
DOI：
10.1002/mds.27872
发表时间：
2020-01
期刊：
Movement disorders : official journal of the Movement Disorder Society
影响因子：
--
作者：
Respondek G;Grimm MJ;Piot I;Arzberger T;Compta Y;Englund E;Ferguson LW;Gelpi E;Roeber S;Giese A;Grossman M;Irwin DJ;Meissner WG;Nilsson C;Pantelyat A;Rajput A;van Swieten JC;Troakes C;Höglinger GU;Movement Disorder Society-Endorsed Progressive Supranuclear Palsy Study Group
通讯作者：
Movement Disorder Society-Endorsed Progressive Supranuclear Palsy Study Group
DOI：
10.1002/mds.27038
发表时间：
2017-07
期刊：
Movement disorders : official journal of the Movement Disorder Society
影响因子：
--
作者：
Whitwell JL;Höglinger GU;Antonini A;Bordelon Y;Boxer AL;Colosimo C;van Eimeren T;Golbe LI;Kassubek J;Kurz C;Litvan I;Pantelyat A;Rabinovici G;Respondek G;Rominger A;Rowe JB;Stamelou M;Josephs KA;Movement Disorder Society-endorsed PSP Study Group
通讯作者：
Movement Disorder Society-endorsed PSP Study Group