Aging induced endoplasmic reticulum stress alters sleep and sleep homeostasis.
Aging induced endoplasmic reticulum stress alters sleep and sleep homeostasis.
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DOI：
10.1016/j.neurobiolaging.2013.12.005
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发表时间：
2014-06
影响因子：
4.2
通讯作者：
Naidoo N
中科院分区：
文献类型：
--
作者：
Brown MK;Chan MT;Zimmerman JE;Pack AI;Jackson NE;Naidoo N
已经证明，在衰老过程中会发生基线和恢复睡眠的质量、数量和结构的改变。睡眠剥夺诱导内质网（ER）应激并上调称为未折叠蛋白反应（UPR）的保护性信号通路。适应性普遍定期审议的有效性随着年龄的增长而降低。先前，我们发现内源性伴侣蛋白水平改变了果蝇的恢复睡眠。我们现在报告说，急性管理的化学伴侣4-苯丁酸钠（PBA）减少内质网应激和改善年龄相关的睡眠变化果蝇。PBA巩固老化果蝇的基线和恢复睡眠。PBA的行为改变与其对ER应激的抑制有关。在睡眠剥夺的果蝇中，PBA降低了x-box结合蛋白1（XBP 1）的剪接和磷酸化延伸起始因子2 α（p-eIF 2 α）的上调。我们还表明，直接激活ER应力在年轻的苍蝇片段基线睡眠和改变恢复睡眠。在衰老过程中缓解长期/持续的ER压力有助于巩固睡眠，并改善恢复睡眠/睡眠债的释放。
Alterations in the quality, quantity and architecture of baseline and recovery sleep have been shown to occur during aging. Sleep deprivation induces endoplasmic reticular (ER) stress and upregulates a protective signaling pathway termed the unfolded protein response (UPR). The effectiveness of the adaptive UPR is diminished by age. Previously, we showed that endogenous chaperone levels altered recovery sleep in Drosophila melanogaster. We now report that acute administration of the chemical chaperone sodium 4-phenylbutyrate (PBA) reduces ER stress and ameliorates age-associated sleep changes in Drosophila. PBA consolidates both baseline and recovery sleep in aging flies. The behavioral modifications of PBA are linked to its suppression of ER stress. PBA decreased splicing of x-box binding protein 1 (XBP1) and upregulation of phosphorylated elongation initiation factor 2 α (p-eIF2α), in flies that were subjected to sleep deprivation. We also demonstrate that directly activating ER stress in young flies fragments baseline sleep and alters recovery sleep. Alleviating prolonged/sustained ER stress during aging contributes to sleep consolidation and improves recovery sleep/ sleep debt discharge.
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影响因子：
64.5
作者：
Sidrauski, C;Walter, P
通讯作者：
Walter, P
影响因子：
2.8
作者：
Rakshit K;Krishnan N;Guzik EM;Pyza E;Giebultowicz JM
通讯作者：
Giebultowicz JM
影响因子：
9.8
作者：
Pincus D;Chevalier MW;Aragón T;van Anken E;Vidal SE;El-Samad H;Walter P
通讯作者：
Walter P
影响因子：
8.3
作者：
Empana, Jean-Philippe;Dauvilliers, Yves;Ducimetiere, Pierre
通讯作者：
Ducimetiere, Pierre
影响因子：
5.6
作者：
Naidoo, Nirinjini;Casiano, Vincent;Pack, Allan I.
通讯作者：
Pack, Allan I.