Developmental vitamin D deficiency alters adult behaviour in 129/SvJ and C57BL/6J mice
Developmental vitamin D deficiency alters adult behaviour in 129/SvJ and C57BL/6J mice
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DOI：
10.1016/j.bbr.2007.09.032
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发表时间：
2008-03-05
影响因子：
2.7
通讯作者：
Burne, Thomas H. J.
中科院分区：
文献类型：
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作者：
Harms, Lauren R.;Eyles, Darryl W.;Burne, Thomas H. J.
发展性维生素D （DVD）缺乏已被认为是许多脑部疾病的环境风险因素。已知大鼠胎儿发育期间缺乏这种维生素会改变成年后的行为，其中许多改变与精神分裂症的临床特征有关。我们研究了DVD缺乏对129/SvJ和C57BL/6J小鼠是否有类似的影响。雌性小鼠在受孕前6周被喂食缺乏维生素D的食物，直到出生，之后老鼠和它们的后代被喂食正常的食物（即含有维生素D）。在整个实验过程中，对照组小鼠喂食正常饮食。成年后代在10周龄时接受了全面的行为测试。我们发现，通过在孔板测试中头部倾斜的频率，两种品系的dvd缺陷小鼠都表现出明显更高的探索水平。此外，dvd缺陷的129/SvJ小鼠，而不是C57BL/6J小鼠，表现出自发的过度运动。母亲饮食对SHIRPA初级筛查评估的参数，或感觉运动门控、社会行为、焦虑或抑郁测试没有影响。其中一些发现类似于大鼠表型（运动过度），但DVD缺乏对小鼠行为也有新的影响（探索增加）。这项研究证实，在发育过程中缺乏这种维生素会影响另一物种（老鼠）的大脑功能，并进一步支持了人类缺乏DVD可能导致不良神经精神结果的假设。(C) 2007 Elsevier B.V.版权所有
Developmental vitamin D (DVD) deficiency has been proposed as an environmental risk factor for a number of brain disorders. The absence of this vitamin during foetal development in the rat is known to alter behaviour in the adult, and many of these alterations are informative with respect to the clinical features of schizophrenia. Here we investigated whether DVD deficiency had a similar effect on 129/SvJ and C57BL/6J mice. Female mice were fed a diet deficient in vitamin D for 6 weeks prior to conception until birth, after which dams and their offspring were fed a normal diet (i.e. containing vitamin D). Control mice were fed a normal diet throughout the experiment. The adult offspring underwent a comprehensive behavioural test battery at 10 weeks of age. We found that DVD-deficient mice of both strains exhibited significantly higher levels of exploration, as measured by the frequency of head dipping on the hole board test. In addition, DVD-deficient 129/SvJ mice, but not C57BL/6J mice, displayed spontaneous hyperlocomotion. There was no effect of maternal diet on parameters assessed by the SHIRPA primary screen, or on tests of sensorimotor gating, social behaviour, anxiety or depression. Some of these findings resemble the rat phenotype (hyperlocomotion) but there are also novel effects of DVD deficiency on mouse behaviour (increased exploration). This study confirms that the developmental absence of this vitamin affects brain function in another species (mouse), and lends further weight to the hypothesis that DVD deficiency in humans may contribute to adverse neuropsychiatric outcomes. (C) 2007 Elsevier B.V. All rights reserved.