Genetic linkage of bipolar disorder to chromosome 6q22 is a consistent finding in Portuguese subpopulations and may generalize to broader populations.
Genetic linkage of bipolar disorder to chromosome 6q22 is a consistent finding in Portuguese subpopulations and may generalize to broader populations.
复制标题
双相情感障碍与染色体 6q22 的遗传联系在葡萄牙亚人群中得到了一致的发现，并且可能推广到更广泛的人群。
DOI：
10.1002/ajmg.b.30159
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Pato,MicheleT
中科院分区：
文献类型：
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作者：
Pato,CarlosN;Middleton,FrankA;Gentile,KarenL;Morley,ChristopherP;Medeiros,Helena;Macedo,Antonio;Azevedo,MHelena;Pato,MicheleT
We recently reported genome‐wide significant linkage to chromosome 6q for bipolar disorder, in a study of 25 Portuguese families, using the Human Mapping Assay Xba 131 (HMA10K). To explore the generalizability of this finding, we reanalyzed our SNP linkage data according to the families' geographic origin. Specifically, the 25 families included 20 families from the Portuguese island collection (PIC; 15 families from the Azores Islands and 5 from the Madeira Islands) and 5 families from continental Portugal. Non‐parametric linkage analysis (NPL) was performed as previously described and indicated that each of these subpopulations showed evidence of linkage for the same region. To further address the potential generalizability of these findings to other populations, we have also examined allelic heterozygosity in our subpopulations and in three reference populations (Caucasian, East Asian, and African‐American). This analysis indicated that the PIC population is highly correlated to the Caucasian reference population (R = 0.86) for all of chromosome 6. In contrast allelic heterozygosity was more weakly correlated between PIC and both East Asian (R = 0.37) and African‐American (R = 0.32) reference populations. Taken together these observations suggest a shared genetic liability among Portuguese populations for bipolar disorder on chromosome 6q, and that the PIC population is likely representative of Caucasians in general. © 2005 Wiley‐Liss, Inc.
