Argyrophilic plaque-like deposits in children.
Argyrophilic plaque-like deposits in children.
复制标题
儿童嗜银斑块状沉积物。
DOI：
10.1007/bf00294258
复制
发表时间：
1995
影响因子：
12.7
通讯作者：
Hulette,CM
中科院分区：
文献类型：
--
作者：
Crain,BJ;McPhatter,L;Croom2nd,DW;Hulette,CM
我们最近检查了一个8个月大的唐氏综合征婴儿的大脑，发现整个新皮层和小脑都有嗜银斑块样沉积物。为了确定这一观察结果的特异性，我们检查了来自儿科尸检服务的27个额外的大脑，其中包括另一名唐氏综合征患者的大脑。令人惊讶的是，在16例病例中发现了类似的嗜银沉积物。这些沉积物被三种不同的银染剂同样染色良好，其大小、形状和在灰质中的分布与成人常见的弥漫性淀粉样斑块相同。然而，这些结构似乎是淀粉样蛋白阴性的。有嗜银沉积物的患者组和无嗜银沉积物的患者组之间的初步诊断没有明显差异，这些斑块样沉积物的起源、持久性和功能意义仍然未知。尽管如此，它们的识别是重要的，因为它们可能代表轻微的脑损伤，并且因为成人中的类似结构可能容易被误解为真正的弥漫性淀粉样斑块。
We recently examined the brain from an 8-month-old infant with Down's syndrome and found argyrophilic plaque-like deposits throughout the neocortex and cerebellum. To ascertain the specificity of this observation, we examined 27 additional brains from the pediatric autopsy service, including 1 from another patient with Down's syndrome. To our surprise, similar argyrophilic deposits were found in 16 of these cases. The deposits were equally well stained by three different silver stains and had the same size, shape, and distribution in gray matter as the diffuse amyloid plaques commonly seen in adults. However these structure appeared to be amyloid negative. There were no obvious differences in the primary diagnoses amongst the group of patients with argyrophilic deposits and the group without them, and the origin, permanence, and functional significance of these plaque-like deposits are still unknown. Nonetheless, their recognition is important since they may represent subtle brain injury and since similar structures in adults might easily be misinterpreted as true diffuse amyloid plaques.