Single intracerebroventricular administration of amyloid-beta (25-35) peptide induces impairment in short-term rather than long-term memory in rats
Single intracerebroventricular administration of amyloid-beta (25-35) peptide induces impairment in short-term rather than long-term memory in rats
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DOI：
10.1016/s0361-9230(03)00118-7
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发表时间：
2003-07-15
影响因子：
3.8
通讯作者：
Gulyaeva, NV
中科院分区：
文献类型：
--
作者：
Stepanichev, MY;Moiseeva, YV;Gulyaeva, NV
大量实验证据表明，向啮齿类动物脑内注射或输注淀粉样β肽（Abeta）会导致学习和记忆障碍以及与认知功能相关的大脑区域的神经变性。在本研究中，我们评估了单次脑室内（i.c.v.）注射15 nmol/大鼠剂量的聚集Abeta片段（25-35）对术后6个月期间大鼠短期和长期记忆的影响。结果表明，Abeta(25-35) 在术后 17、36 和 180 天的 Y 迷宫自发交替行为以及术后 110 天的社会识别任务中引起记忆障碍。 Abeta(25-35) 也会损害 8 臂径向迷宫中的空间记忆，但不影响逐步下降的被动回避任务的表现。这些结果表明，Abeta(25-35) 更容易诱导大鼠空间和非空间短期（工作）记忆而不是长期记忆的损伤。 (C) 2003 Elsevier Science Inc. 保留所有权利。
Ample experimental evidence indicates that intracerebral injection or infusion of amyloid-beta peptides (Abeta) to rodents induces learning and memory impairments as well as neurodegeneration in brain areas related to cognitive function. In the present study, we assessed the effects of a single intracerebroventricular (i.c.v.) injection of aggregated Abeta fragment (25-35) at a dose of 15 nmol/rat on short-term and long-term memory in rats during the 6-month post-surgery period. The results demonstrate that Abeta(25-35)-induced memory impairments in spontaneous alternation behavior in a Y-maze at 17, 36, and 180 days after the surgery as well as in a social recognition task 110 days post-surgery. Abeta(25-35) also impaired spatial memory in an 8-arm radial maze, but did not influence performance of the step-down passive avoidance task. These results suggest that Abeta(25-35) preferably induces impairments of spatial and non-spatial short-term (working) memory rather than long-term memory in rats. (C) 2003 Elsevier Science Inc. All rights reserved.