Caregiver distress associated with behavioral and psychological symptoms in mild Alzheimer's disease.
Caregiver distress associated with behavioral and psychological symptoms in mild Alzheimer's disease.
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DOI：
10.1590/s1980-57642010dn40300013
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发表时间：
2010-07
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影响因子：
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通讯作者：
do Vale FAC
中科院分区：
文献类型：
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作者：
Balieiro AP Jr;Sobreira EST;Pena MCS;Silva-Filho JH;do Vale FAC
本研究的目的是分析轻度阿尔茨海默病的照顾者苦恼与痴呆的行为和心理症状之间的关系。使用神经精神病学问卷(NPI)对50名患者和照顾者进行了采访。96.0%的患者至少有一次BPSD。NPI总分平均19.6分(SD=18.05，范围0~78)，照顾者痛苦指数(CDI)总分平均11.5分(SD=10.41，范围0~40)。对于个别症状，加权平均CDI为2.8(SD=1.58)。除欣快感/欣快感(m=1.8；SD=1.49)外，其余症状CDI均值均大于2.0。除去抑制和夜间行为外，CDI与所有症状的衍生测量(频率、严重程度、FXS和幅度)之间存在相关性。相关系数在0.443到0.894之间，有统计学意义。所有派生的测量，包括幅度，至少在某些情况下是有用的。这些数据表明，CDI不能从症状存在或特征中推断出来。应对症状进行系统调查。
The aim of this study was to analyze the relationship between Caregiver Distress and Behavioral and Psychological Symptoms in Dementias (BPSD) in mild Alzheimer’s disease. Fifty patients and caregivers were interviewed using the Neuropsychiatric Inventory (NPI). 96.0% of the patients had at least one BPSD. The mean NPI total score was 19.6 (SD=18.05; range=0-78) whereas the mean Caregiver Distress Index (CDI) total score was 11.5 (SD=10.41; range=0-40). For the individual symptoms, the weighted mean CDI was 2.8 (SD=1.58). All symptom CDI means were higher than 2.0 except for euphoria/elation (m=1.8; SD=1.49). There were correlations between CDI and derived measures (Frequency, Severity, FxS, and Amplitude) for all symptoms, except Disinhibition and Night-time behavior. Correlations ranged between 0.443 and 0.894, with significance at p<0.05. All the derived measures, including amplitude, were useful in at least some cases. The data suggests that CDI cannot be inferred from symptom presence or profile. Symptoms should be systematically investigated.