The asbestos-carbon nanotube analogy: An update
The asbestos-carbon nanotube analogy: An update
复制标题
DOI：
10.1016/j.taap.2018.06.027
复制
发表时间：
2018-12-15
影响因子：
3.8
通讯作者：
Gao, Huajian
中科院分区：
文献类型：
--
作者：
Kane, Agnes B.;Hurt, Robert H.;Gao, Huajian
纳米技术是一种基于100纳米或更小尺寸的材料商业化的新兴产业。工程纳米材料目前被纳入薄膜、多孔材料、液体悬浮液或填料/基质纳米复合材料中，预计未来的应用将涉及能源和催化、微电子、环境传感和修复以及纳米医学。碳纳米管是一维纤维纳米材料，物理上类似于石棉纤维。对啮齿动物的毒理学研究表明，某些类型的碳纳米管可诱发间皮瘤，世界卫生组织在 2014 年评估了长而刚性的多壁碳纳米管可能对人类致癌。这篇综述总结了石棉纤维和碳纳米管之间的主要物理化学相似点和差异。 “纤维致病性范式”已扩展到包括碳纳米管以及其他高纵横比纤维纳米材料，包括金属纳米线。该范例将高纵横比纤维纳米材料的宽度、长度和生物持久性确定为吸入后肺部疾病（包括间皮瘤）的关键决定因素。根据最近的理论模型研究，第四个因素，即机械弯曲刚度，将被视为潜在致癌性的预测因素。新型三维肺组织平台为在商业化之前体外筛选各种高长径比纤维纳米材料的潜在肺毒性提供了机会。
Nanotechnology is an emerging industry based on commercialization of materials with one or more dimensions of 100 nm or less. Engineered nanomaterials are currently incorporated into thin films, porous materials, liquid suspensions, or filler/matrix nanocomposites with future applications predicted in energy and catalysis, microelectronics, environmental sensing and remediation, and nanomedicine. Carbon nanotubes are one-dimensional fibrous nanomaterials that physically resemble asbestos fibers. Toxicologic studies in rodents demonstrated that some types of carbon nanotubes can induce mesothelioma, and the World Health Organization evaluated long, rigid multiwall carbon nanotubes as possibly carcinogenic for humans in 2014. This review summarizes key physicochemical similarities and differences between asbestos fibers and carbon nanotubes. The "fiber pathogenicity paradigm" has been extended to include carbon nanotubes as well as other high-aspect-ratio fibrous nanomaterials including metallic nanowires. This paradigm identifies width, length, and biopersistence of high-aspect-ratio fibrous nanomaterials as critical determinants of lung disease, including mesothelioma, following inhalation. Based on recent theoretical modeling studies, a fourth factor, mechanical bending stiffness, will be considered as predictive of potential carcinogenicity. Novel three-dimensional lung tissue platforms provide an opportunity for in vitro screening of a wide range of high aspect ratio fibrous nanomaterials for potential lung toxicity prior to commercialization.