Autophagy regulated by miRNAs in colorectal cancer progression and resistance.
Autophagy regulated by miRNAs in colorectal cancer progression and resistance.
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DOI：
10.4103/ctm.ctm_64_16
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发表时间：
2017
影响因子：
--
通讯作者：
Ju J
中科院分区：
文献类型：
--
作者：
Fesler A;Liu H;Wu N;Liu F;Ling P;Ju J
自噬的分解代谢过程是一种重要的细胞功能，可以分解和回收细胞大分子。近年来，非编码 microRNA (miRNA) 对自噬的表观遗传调控的影响已在人类癌症中得到认识。在结直肠癌中，自噬在癌症进展以及化疗耐药中发挥着关键作用，最近的证据表明 miRNA 直接参与介导这些功能。在这篇综述中，我们将重点关注 miRNA 调控结直肠癌自噬领域的最新进展。
The catabolic process of autophagy is an essential cellular function that allows for the breakdown and recycling of cellular macromolecules. In recent years, the impact of epigenetic regulation of autophagy by non-coding microRNAs (miRNAs) has been recognized in human cancer. In colorectal cancer, Autophagy plays critical roles in cancer progression as well as resistance to chemotherapy, and recent evidence demonstrates that miRNAs are directly involved in mediating these functions. In this review, we will focus on the recent advancements in the field of miRNA regulation of autophagy in colorectal cancer.