A basic fibroblast growth factor improved the quality of skin grafting in burn patients
A basic fibroblast growth factor improved the quality of skin grafting in burn patients
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DOI：
10.1016/j.burns.2005.04.008
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发表时间：
2005-11-01
期刊：
影响因子：
2.7
通讯作者：
Hirano, A
中科院分区：
文献类型：
--
作者：
Akita, S;Akino, K;Hirano, A
为避免烧伤后瘢痕增生，采用临床观察和仪器测定的方法，研究了碱性成纤维细胞生长因子（bFGF）与常规手术清创植皮同时应用对烧伤创面皮肤硬度的影响。由于对bFGF在伤口中的作用知之甚少，测试了烧伤伤口瘢痕的硬度。在最终伤口愈合后至少1年的不同解剖位置的烧伤瘢痕中，临床证明bFGF治疗伤口的硬评分显著低于非bFGF伤口（分别为0.95 +/-0.51和2.3 +/-0.66，p < 0.01）。此外，在工业中广泛用于测量类似于皮肤的材料（如橡胶和线球）的硬度计显示，bFGF治疗伤口的阅读显著低于非bFGF伤口（分别为7.9 +/- 3.64 vs 15.5 +/- 4.39，bFGF vs非bFGF，p < 0.01）。结果表明，用临床批准的bFGF治疗的烧伤伤口可能有助于更好的皮肤伤口质量，至少在硬度方面。(c)2005年爱思唯尔有限公司和ISB 1。All rights reserved.
To avoid hypertrophic scars in burn wounds, the simultaneous application of basic fibroblast growth factor (bFGF) with regular surgical debridement and skin grafting was investigated for skin hardness by clinical examination and instrumental measurement. As little is known about the role of bFGF in wounds, burn wound scars were tested for hardness. Burn scars in various anatomical locations at least I year after final wound healing clinically demonstrated a significantly lower hard score in bFGF-treated wounds than in non-bFGF wounds (0.95 +/- 0.51 versus 2.3 +/- 0.66, respectively, p < 0.01). In addition, a durometer, which is widely used in industry to measure materials similar to skin, such as rubber and thread-balls, demonstrated a significantly lower reading in bFGF-treated wounds than in non-bFGF wounds (7.9 +/- 3.64 versus 15.5 +/- 4.39, bFGF versus non-bFGF, respectively, p < 0.01). The results demonstrated that burn wounds treated with clinically approved bFGF might contribute to a better cutaneous wound quality, at least in terms of hardness. (c) 2005 Elsevier Ltd and ISB1. All rights reserved.