Moving free radical and redox biology ahead in the next decade(s).
Moving free radical and redox biology ahead in the next decade(s).
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DOI：
10.1016/j.freeradbiomed.2014.10.578
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发表时间：
2015-01
影响因子：
7.4
通讯作者：
Buettner, Garry R.
中科院分区：
文献类型：
--
作者：
Buettner, Garry R.
1954年对生物样品中自由基的直接观察为几十年来的推断提供了支持，即活的，功能齐全的生物体产生自由基[1]。在此之后，结合辐射生物学的观察，哈曼提出了衰老的自由基理论，该理论仍在积极研究中[2]。超氧化物歧化酶的发现沿着人们认识到酶可以产生自由基，这为自由基在生物学中的作用带来了全新的视角[3]。最初的研究集中在：各种自由基和相关氧化剂的基本化学性质;对细胞和组织的潜在氧化损伤;以及自由基/氧化剂可能在细胞和组织中造成的机制和后果。然而，随着人们意识到超氧化物和相关氧化剂与超氧化物歧化酶一起是细胞和组织的基本生物学的一部分，这种关注慢慢改变[4]。由于细胞和组织中可以产生广泛的活性物质，对于许多氧化剂，术语“活性氧（ROS）"沿着“氧化应激”，为了表示这些氧化剂的破坏性化学反应的后果，在20世纪80年代引入了[5];该词汇表是一种为该领域带来更全面和包容性观点的手段。然而，这些术语现在似乎是自由基和氧化还原生物学领域研究进展的障碍，因为它们提供了非常一般的信息，而不是更深入理解所需的详细信息。
The direct observation of free radicals in biological samples in 1954 provided support for what had been inferred for several decades, ie living, fully functioning organisms produce free radicals [1]. Following this, in conjunction with observations from radiation biology, Harman proposed the free radical theory of aging that is still being actively investigated [2]. The discovery of superoxide dismutase along with the realization that enzymes can make free radicals brought an entirely new view to the role of free radicals in biology [3]. Initially research focused on: the basic chemistry of the various free radicals and related oxidants; potential oxidative damage to cells and tissues; and the mechanisms and consequences that free radicals/oxidants could inflict in cells and tissues. However, this focus slowly changed as it was realized that superoxide and related oxidants in conjunction with superoxide dismutases are part of the basic biology of cells and tissues [4].Because of the wide range of reactive species that could be generated in cells and tissues, the terms “reactive oxygen species (ROS)”, for the many oxidants, along with “oxidative stress”, to represent the consequence due to the damaging chemical reactions of these oxidants, were introduced in the 1980’s [5]; this vocabulary was a means to bring a more comprehensive and inclusive view to the field. However, these terms now appear to be a hindrance to the advancement of research in the field of free radical and redox biology because they provide very general information rather than the detailed information needed for deeper understanding.
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DOI：
10.1073/pnas.0903485106
发表时间：
2009-05-26
影响因子：
11.1
作者：
Ristow, Michael;Zarse, Kim;Blueher, Matthias
通讯作者：
Blueher, Matthias
单线粒体中的超氧化物闪光
影响因子：
64.5
作者：
Wang, Wang;Fang, Huaqiang;Groom, Linda;Cheng, Aiwu;Zhang, Wanrui;Liu, Jie;Wang, Xianhua;Li, Kaitao;Han, Peidong;Zheng, Ming;Yin, Jinhu;Wang, Weidong;Mattson, Mark P.;Kao, Joseph P. Y.;Lakatta, Edward G.;Sheu, Shey-Shing;Ouyang, Kunfu;Chen, Ju;Dirksen, Robert T.;Cheng, Heping
通讯作者：
Cheng, Heping
影响因子：
7.4
作者：
Bonini, MG;Rota, C;Mason, RP
通讯作者：
Mason, RP
影响因子：
4.8
作者：
Liu, XP;Samouilov, A;Zweier, JL
通讯作者：
Zweier, JL
影响因子：
7.4
作者：
Benfeitas, Rui;Selvaggio, Gianluca;Salvador, Armindo
通讯作者：
Salvador, Armindo