Connective tissue structure: cell binding to collagen.
Connective tissue structure: cell binding to collagen.
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结缔组织结构：细胞与胶原蛋白结合。
DOI：
10.1111/1523-1747.ep12543641
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
George R. Martin
中科院分区：
文献类型：
--
作者：
H. Kleinman;J Clifford Murray;E. McGoodwin;George R. Martin
已建立的成纤维细胞系通过血清衍生的糖蛋白粘附在胶原底物上。这里检查了各种其他细胞与I-IV型胶原蛋白的附着。人皮肤成纤维细胞、骨膜、肝细胞、结缔组织细胞和单核细胞等细胞需要血清糖蛋白，并能很好地粘附于所有胶原，但软骨细胞、表皮细胞和中性粒细胞的粘附被血清糖蛋白抑制。附着的2个致瘤细胞，一个骨肉瘤和一个纤维肉瘤，发现不受血清糖蛋白的影响。此外，纤维肉瘤和表皮细胞优先附着于IV型（基底膜）胶原。
Established lines of fibroblasts have been shown to adhere to collagen substrates via a serum-derived glycoprotein. The attachment of various other cells to collagen types I-IV is examined here. Cells such as human skin fibroblasts, periosteum, hepatocytes, connective tissue cells, and monocytes required the serum glycoprotein and adhered equally well to all collagens, but attachment of chondrocytes, epidermal cells, and neutrophils was inhibited by the serum glycoprotein. Attachment of 2 tumorigenic cells, an osteosarcoma and a fibrosarcoma, was found to be unaffected by the serum glycoprotein. In addition, the fibrosarcoma and epidermal cells attached preferentially to type IV (basement membrane) collagen.