Is Midlife Metabolic Syndrome Associated With Cognitive Function Change? The Study of Women's Health Across the Nation
Is Midlife Metabolic Syndrome Associated With Cognitive Function Change? The Study of Women's Health Across the Nation
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中年代谢综合征与认知功能改变有关吗？全国妇女健康状况调查报告
DOI：
10.1210/clinem/dgaa067
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发表时间：
2020-04-01
影响因子：
5.8
通讯作者：
Kravitz, Howard M.
中科院分区：
文献类型：
--
作者：
Kazlauskaite, Rasa;Janssen, Imke;Kravitz, Howard M.
背景：代谢综合征（MetS）影响晚年的认知功能，特别是女性。但是关于代谢综合征与中年认知功能的关系的纵向研究很少。目的：确定代谢综合征暴露与中年妇女认知功能轨迹之间的关系。设计和设置：这是一项为期17年的前瞻性纵向研究，对美国7个社区的多种族/民族妇女进行了年度/两年一次的评估。参与者：参与者为2149名正在经历更年期的美国妇女。暴露包括MetS评估主要结果测量：主要结果测量是在3个领域的认知功能评估：感知速度（符号数字模式测试，SDMT），情景记忆（东波士顿记忆测试，EBMT）和工作记忆结果：通过他们的第一次认知评估（年龄50.7 ± 2.9岁），29.5%符合MetS的标准。女性在11.2（IQR 9.2-11.5）年内完成了中位数（四分位距[IQR]）6（IQR 4-7）的随访认知评估。在调整认知测试实践影响、社会人口统计学、生活方式、情绪和绝经因素后，与未患MetS的女性相比，患有MetS的女性在SDMT z评分方面有更大的10年下降（估计值-0.087，95%置信区间，-0.150至-0.024; P = 0.007）。因此，MetS将感知速度的10年损失加速了24%。MetS并没有显着影响下降的速度，无论是即时（P = 0.534）或延迟（P = 0.740）情节记忆或工作记忆（P = 0.584）。结论：在中年妇女MetS暴露与知觉速度的加速下降，但不是情节或工作记忆。
Context: Metabolic syndrome (MetS) affects cognitive function in late life, particularly in women. But longitudinal research is scarce on associations of MetS with cognitive function during midlife.Objective: To determine associations between MetS exposure and cognitive function trajectories in midlife women.Design and Setting: This is a 17-year prospective, longitudinal study of multiracial/ethnic women in 7 US communities, with annual/biennial assessments.Participants: Participants were 2149 US women traversing menopause.Exposure: Exposure consisted of MetS assessments (median 4 assessments over 4 years).Main Outcome Measures: Main outcome measures were assessments of cognitive function in 3 domains: perceptual speed (symbol digit modalities test, SDMT), episodic memory (East Boston Memory Test, EBMT), and working memory (Digit Span Backward Test, DSB).Results: By their first cognitive assessment (age 50.7 +/- 2.9 years), 29.5% met the criteria for MetS. Women completed a median (interquartile range [IQR]) of 6 (IQR 4-7) follow-up cognitive assessments over 11.2 (IQR 9.2-11.5) years. Women with MetS, compared with those without, had a larger 10-year decline in SDMT z-score (estimate -0.087, 95% confidence interval, -0.150 to -0.024; P = 0.007), after adjustment for cognitive testing practice effects, sociodemographics, lifestyle, mood, and menopause factors. As such, MetS accelerated the 10-year loss of perceptual speed by 24%. MetS did not differentially affect the rate of decline in either immediate (P = 0.534) or delayed (P = 0.740) episodic memory or in working memory (P = 0.584).Conclusions: In midlife women MetS exposure was associated with accelerated decline in perceptual speed, but not episodic or working memory.