[On the clinical relevance of clozapine-triggered release of cytokines and soluble cytokine-receptors].
[On the clinical relevance of clozapine-triggered release of cytokines and soluble cytokine-receptors].
复制标题
[氯氮平触发细胞因子和可溶性细胞因子受体释放的临床相关性]。
DOI：
--
复制
发表时间：
2001
影响因子：
0.6
通讯作者：
D. Hinze‐Selch
中科院分区：
文献类型：
--
作者：
T. Pollmächer;A. Schuld;T. Kraus;M. Haack;D. Hinze‐Selch
细胞因子是免疫活性细胞间相互作用的关键介质。此外，它们还调节免疫系统和包括中枢神经系统在内的其他生理系统之间的相互作用。最近的研究表明，抗精神病药物氯氮平在体内可以刺激细胞因子和可溶性细胞因子受体的释放。肿瘤坏死因子系统、白介素2系统、白介素6和粒细胞集落刺激因子也是如此。本文讨论了这些发现与氯氮平引起的副作用的病理生理学的临床相关性。肿瘤坏死因子-α很可能在氯氮平引起的发热和包括粒细胞缺乏症在内的造血副作用中发挥重要作用。此外，肿瘤坏死因子和其他细胞因子很可能参与代谢(体重增加、糖尿病)、心脏(心肌炎)、中枢神经系统(镇静)和其他罕见的副作用。氯氮平诱导免疫调节的机制尚不清楚。因此，进一步的研究对于加深我们对氯氮平副作用的了解和制定预防和治疗策略是非常重要的。
Cytokines are pivotal mediators of the interaction between immunocompetent cells. Moreover, they mediate the interaction between the immune system and other physiological systems, including the CNS. It has been shown recently that the antipsychotic drug clozapine stimulates in vivo the release of cytokines and soluble cytokine receptors. This holds true for the tumor necrosis factor(TNF)-system, the interleukin(IL)-2-system, IL-6, and granulocyte colony-stimulating factor (G-CSF). The present paper discusses the clinical relevance of these findings for the pathophysiology of clozapine-induced side-effects. It is very probable that TNF-alpha plays an important role in clozapin-induced fever and in the hematopoetic side effects, including agranulocytosis. Moreover, it is likely that TNF-alpha and other cytokines are involved in metabolic (weight gain, diabetes), cardiac (myocarditis), CNS (sedation) and other rare side effects. The mechanisms underlying clozapine-induced immunomodulation are unknown. Hence, further studies are very important to enhance our understanding of clozapins's side effects and to develop strategies for prevention and treatment.