Vocal training, levodopa, and environment effects on ultrasonic vocalizations in a rat neurotoxin model of Parkinson disease.
Vocal training, levodopa, and environment effects on ultrasonic vocalizations in a rat neurotoxin model of Parkinson disease.
复制标题
人声训练，左旋多巴和环境对帕金森氏病大鼠神经毒素模型超声声音的影响。
DOI：
10.1016/j.bbr.2016.03.006
复制
发表时间：
2016-07-01
影响因子：
2.7
通讯作者：
Ciucci MR
中科院分区：
文献类型：
--
作者：
Kelm-Nelson CA;Brauer AF;Ciucci MR
左旋多巴并不能改善帕金森病(PD)患者的构音障碍，尽管“LSVT/OUTH®”等发声训练疗法确实能改善发声交流。大多数患者在接受左旋多巴治疗的同时接受发声训练治疗，尽管左旋多巴和发声训练疗法对帕金森病患者沟通的相互作用相对未知。此外，将发声训练疗法带到新的情境中是成功的关键，但新情境对康复发声交流的影响还不是很清楚。为了通过精确的实验控制来解决运动、药物和环境对发声交流的影响，我们使用了广泛使用的6-OHDA大鼠神经毒素模型PD(内侧前脑束输注)，并评估了发声训练、左旋多巴发声训练、左旋多巴单独发声和对照条件下的超声发声。我们在熟悉的家庭笼子和新型笼子的训练环境中测试了无人潜航器。我们假设，与对照组和左旋多巴治疗组相比，接受发声训练的帕金森病大鼠的超声发声(USV)声学参数将有显著改善。我们进一步假设，发声训练与左旋多巴给药的结合，与人类常见的情况类似，将导致USV结果的改善，特别是在熟悉的环境和新的环境中进行测试时。我们发现，运动和左旋多巴的结合导致了一些USV声学参数的改善，并且这些影响在熟悉的环境中比在陌生的环境中更强。我们的结果表明，虽然治疗可以改善沟通的各个方面，但环境可能会影响这些效果的好处。
Levodopa does not improve dysarthria in patients with Parkinson Disease (PD), although vocal exercise therapy, such as “LSVT/LOUD®”, does improve vocal communication. Most patients receive vocal exercise therapy while concurrently being treated with levodopa, although the interaction between levodopa and vocal exercise therapy on communication in PD is relatively unknown. Further, carryover of vocal exercise therapy to novel situations is critical for successful outcomes, but the influence of novel situations on rehabilitated vocal communication is not well understood. To address the influence of exercise, medications, and environment on vocal communication with precise experimental control, we employed the widely used 6-OHDA rat neurotoxin model of PD (infusion to the medial forebrain bundle), and assessed ultrasonic vocalizations after: vocal exercise, vocal exercise with levodopa, levodopa alone, and control conditions. We tested USVs in the familiar training environment of the home cage and a novel cage. We hypothesized that parkinsonian rats that undergo vocal exercise would demonstrate significant improvement of ultrasonic vocalization (USV) acoustic parameters as compared to the control exercise and levodopa-only treatment groups. We further hypothesized that vocal exercise in combination with levodopa administration, similar to what is common in humans, would lead to improvement in USV outcomes, particularly when tested in a familiar versus a novel environment. We found that the combination of exercise and levodopa lead to some improvement in USV acoustic parameters and these effects were stronger in a familiar vs. a novel environment. Our results suggest that although treatment can improve aspects of communication, environment can influence the benefits of these effects.