Prophylactic amiodarone and lidocaine improve survival in an ovine model of large size myocardial infarction.
Prophylactic amiodarone and lidocaine improve survival in an ovine model of large size myocardial infarction.
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DOI：
10.1016/j.jss.2013.05.050
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发表时间：
2013-11
影响因子：
2.2
通讯作者：
Griffith, Bartley P.
中科院分区：
文献类型：
--
作者：
Li, Tieluo;Wei, Xufeng;Watkins, A. Claire;Sanchez, Pablo G.;Wu, Zhongjun J.;Griffith, Bartley P.
Large animal models serve as a critical link in the translation of basic science to clinical practice. However, large animal models of MI, especially a large size MI, are associated with high mortality due to arrhythmia. The prophylactic effect of amiodarone and lidocaine were retrospectively reviewed in our ovine MI model. One hundred-fourteen Dorset hybrid sheep with 25–30% MI were included in this study. Animals were prophylacticly treated with amiodarone plus lidocaine before ligation of the 4–6 coronary artery branches supplying the apex of the heart (arrhythmia-prevention group, AP group, n=45) and with epinephrine (shock-prevention group, SP group, n=49), respectively. Animals without prophylactic treatment (no-prevention group, NP group, n=20) were used as the control group. The incidence of arrhythmia requiring treatment, mortality due to arrhythmias, hemodynamics and arterial blood gas values during the surgery were analyzed in these three groups. There was no significant difference in infarct size among the three groups. The incidence of arrhythmia requiring treatment was significantly decreased in the AP group compared to the NP or SP groups 4.4% (AP) vs. 35% (SP) or 45% (NP) p<0.05). The mortality due to lethal arrhythmia was 2.2% in the AP group, significantly lower than in the NP group (15%) or the SP group (18.4%). Besides heart rate (HR), hemodynamic data there were no significant differences between the AP and NP group. Metabolic acidosis was not observed in any group as indicated by pH and lactate values. Prophylactic amiodarone plus lidocaine decreased the mortality due to lethal arrhythmia after acute myocardial infarction in our sheep model without significant negative effect on hemodynamics. However, epinephrine improved hemodynamics but also increased mortality due to lethal arrhythmia. Thus, prophylactic amiodarone plus lidocaine is recommended to improve the stability in a large MI animal model.
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影响因子：
18.2
作者：
Lacey, L;Tabberer, M
通讯作者：
Tabberer, M
影响因子：
4.4
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Hakkinen, Unto;Hartikainen, Juha;Tierala, Ilkka
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Tierala, Ilkka
影响因子：
2.8
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Criley, JM
影响因子：
2.4
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Chen FY
影响因子：
4.8
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WEINBERG, BA;MILES, WM;ZIPES, DP
通讯作者：
ZIPES, DP