Sequencing Disparity in the Genomic Era
Sequencing Disparity in the Genomic Era
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DOI：
10.1093/molbev/msz117
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发表时间：
2019-08-01
影响因子：
10.7
通讯作者：
Halanych, Kenneth M.
中科院分区：
文献类型：
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作者：
David, Kyle T.;Wilson, Alan E.;Halanych, Kenneth M.
测序技术的进步使人们期望基因组研究将更能代表生物多样性。为了验证这一期望，我们在序列读取档案中探索了非人类真核生物的物种代表。随着时间的推移，物种丰富度一直在稳步增加，但物种均匀度却在下降。此外，研究最多的前1%的生物在全部实验中所占的比例越来越大，这表明对少数物种的偏袒越来越大。为了更好地理解分子过程和模式，基因组研究应该通过采用更多的比较方法来扭转目前的趋势。
Advances in sequencing technology have resulted in the expectation that genomic studies will become more representative of organismal diversity. To test this expectation, we explored species representation of nonhuman eukaryotes in the Sequence Read Archive. Though species richness has been increasing steadily, species evenness is decreasing over time. Moreover, the top 1% most studied organisms increasingly represent a larger proportion of total experiments, demonstrating growing bias in favor of a small minority of species. To better understand molecular processes and patterns, genomic studies should reverse current trends by adopting more comparative approaches.