Complex Economic Behavior Patterns Are Constructed from Finite, Genetically Controlled Modules of Behavior
Complex Economic Behavior Patterns Are Constructed from Finite, Genetically Controlled Modules of Behavior
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DOI：
10.1016/j.celrep.2019.07.038
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发表时间：
2019-08-13
期刊：
影响因子：
8.8
通讯作者：
Gregg, Christopher
中科院分区：
文献类型：
--
作者：
Homdli, Cornelia N. Stacher;Wong, Eleanor;Gregg, Christopher
复杂的行为学行为可以从有限的模块中构建出来，这些模块是行为的可重复功能单元。在这里，我们测试了这个觅食的想法，并开发了方法来剖析小鼠的丰富行为模式。我们发现了不同品系和年龄的觅食行为可重复的离散模块，以及非模块化行为序列。模块在形式、表达频率和表达时间方面不同，并且以概率确定的顺序表达。模块塑造喂养，暴露，活动和持续反应的经济模式。觅食的模块化结构的变化发展，不同的发展，遗传和父母的影响被发现塑造特定模块的表达。从复杂模式中剖析模块对于表型分析是非常强大的。我们发现印记普拉德-威利综合征基因Magel 2的两个双亲等位基因在小鼠中都有功能，但调节不同的模块。我们的研究发现，复杂的经济模式是由有限的、遗传控制的模块构建的。
Complex ethological behaviors could be constructed from finite modules that are reproducible functional units of behavior. Here, we test this idea for foraging and develop methods to dissect rich behavior patterns in mice. We uncover discrete modules of foraging behavior reproducible across different strains and ages, as well as nonmodular behavioral sequences. Modules differ in terms of form, expression frequency, and expression timing and are expressed in a probabilistically determined order. Modules shape economic patterns of feeding, exposure, activity, and perseveration responses. The modular architecture of foraging changes developmentally, and different developmental, genetic, and parental effects are found to shape the expression of specific modules. Dissecting modules from complex patterns is powerful for phenotype analysis. We discover that both parental alleles of the imprinted Prader-Willi syndrome gene Magel2 are functional in mice but regulate different modules. Our study found that complex economic patterns are built from finite, genetically controlled modules.