Angiogenesis by implantation of peripheral blood mononuclear cells and platelets into ischemic limbs (Retracted Article)
Angiogenesis by implantation of peripheral blood mononuclear cells and platelets into ischemic limbs (Retracted Article)
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DOI：
10.1161/01.cir.0000031332.45480.79
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发表时间：
2002-10-08
期刊：
影响因子：
37.8
通讯作者：
Iwasaka, T
中科院分区：
文献类型：
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作者：
Iba, O;Matsubara, H;Iwasaka, T
背景：外周血单核细胞（pbmnc）、血小板和多形核白细胞（PMNs）含有多种血管生成因子和细胞因子。方法与结果：手术诱导胸腺裸大鼠单侧后肢缺血，将荧光标记的人血细胞(PBMNCs[10(7)细胞]+血小板[10(9)]或PBMNCs[10(7)]+血小板[10（9)]+PMNs[10(7)]）肌内植入缺血肢体。激光多普勒显像显示PBMNC+血小板植入肢体的血流灌注明显增加(增加44%，P
Background-Peripheral blood mononuclear cells (PBMNCs), platelets, and polymorphonuclear leukocytes (PMNs) contain various angiogenic factors and cytokines.Methods and Results-Unilateral hindlimb ischemia was surgically induced in athymic nude rats, and fluorescence-labeled human blood cells (PBMNCs [10(7) cells] +platelets [10(9)] or PBMNCs [10(7)]+platelets [10(9)]+PMNs [10(7)]) were intramuscularly implanted into the ischemic limbs. Laser Doppler imaging revealed markedly increased blood perfusion in PBMNC+platelet-implanted limbs (44% increase, P